STI571 (imatinib mesylate): the tale of a targeted therapy

Anti-cancer Drugs
Paul Thambi, Edward A Sausville

Abstract

STI571 (imatinib mesylate) is an example of the successful development of a targeted agent. Its target is the constitutively active tyrosine kinase (p210bcr-abl) in a hematologic neoplasm, chronic myelogenous leukemia (CML). The results in early clinical trials were remarkable and led to rapid approval by the Food and Drug Administration for clinical use of the STI571 in CML. This article reviews the pre-clinical and clinical development of this agent and also discusses some of the prevailing theories to explain the emerging problem of resistance. Future directions for this drug, possibly directed at other targets, are also discussed.

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Citations

Jul 27, 2004·American Journal of Clinical Pathology·Pamela M Guerriere-KovachMark R Wick
Jan 17, 2015·Journal of the American Academy of Dermatology·James B MacdonaldAleksandar Sekulic
Sep 13, 2003·Leukemia·E OlavarriaUNKNOWN Chronic Leukaemia Working Party of the European Group of Bone and Marrow Transplantation (EBMT)
Sep 4, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Juliane M JürgensmeierRoy S Herbst
Feb 16, 2007·Journal of Medicinal Chemistry·Alex M AronovXiaoling Xie

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