Stiffness Value and Serum Biomarkers in Liver Fibrosis Staging: Study in Large Surgical Specimens in Patients with Chronic Hepatitis B

Radiology
Qiang LuYan Luo

Abstract

Purpose To investigate the capabilities of stiffness value and serum biomarkers in the staging of liver fibrosis in patients with chronic hepatitis B (CHB), with pathologic findings in large surgical specimens serving as the reference standard. Materials and Methods This study was approved by the institutional review board, and informed consent was obtained from all patients. Liver stiffness (determined by means of ultrasonography-based elastography point quantification), aspartate aminotransferase-platelet ratio index (APRI), and fibrosis index (based on the four-factor Fibrosis-4 [FIB-4] calculation) were obtained in 386 patients with CHB. With pathologic fibrosis stages in large surgical specimens as the reference standard, capabilities and cutoffs of stiffness and serum biomarkers were first investigated in a cohort of 284 patients and then validated in an independent cohort of 102 patients by means of area under the receiver operating characteristic curve (AUC) analysis. Results Liver stiffness demonstrated significantly stronger correlation with fibrosis stages than did APRI and FIB-4 (r = 0.738 vs r = 0.477 vs r = 0.427, respectively; P < .05 for all). In the development cohort, liver stiffness had significantly higher A...Continue Reading

References

Jun 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·V J DesmetP J Scheuer
Aug 29, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J F CadranelF Degos
May 7, 2002·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Laurent SandrinMathias Fink
Oct 19, 2002·The American Journal of Gastroenterology·Arie RegevEugene R Schiff
Dec 4, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Pierre BedossaValerie Paradis
May 14, 2004·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Jérémy BercoffMathias Fink
Jun 15, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Anaïs Vallet-PichardStanislas Pol
Jul 5, 2007·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Eiichi OgawaJun Hayashi
Jul 14, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Chee-Kin HuiUNKNOWN Hong Kong Liver Fibrosis Study Group
Aug 21, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Abdel Aziz M Shaheen, Robert P Myers
Mar 13, 2008·Journal of Hepatology·Laurent CasteraAlfredo Alberti
Oct 11, 2008·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Emmet B KeeffeHillel Tobias
Aug 2, 2011·The Turkish Journal of Gastroenterology : the Official Journal of Turkish Society of Gastroenterology·Fatih GüzelbulutAyşe Oya Kurdaş Övünç
Feb 1, 2012·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Elliot B TapperNezam Afdhal
Mar 23, 2012·Journal of Hepatology·UNKNOWN European Association For The Study Of The Liver
Nov 3, 2012·European Journal of Radiology·Wenwu LingYan Luo
Mar 21, 2013·European Journal of Gastroenterology & Hepatology·Fatma UcarErdem Akbal
Sep 12, 2013·World Journal of Hepatology·Mehmet CelikbilekMehmet Yucesoy
Oct 25, 2013·Indian Journal of Pathology & Microbiology·Rakesh ShrivastavaSatyajit Singh Gill
Jun 1, 2012·Hepatology International·Yun-Fan LiawMasao Omata

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Citations

Jun 3, 2016·Middle East Journal of Digestive Diseases·Mohammad Reza FattahiMehrzad Lotfi
Oct 5, 2016·Middle East Journal of Digestive Diseases·Hedyeh EbrahimiAmir Ali Sohrabpour
Jan 14, 2022·Abdominal Radiology·Sudhakar K Venkatesh, Michael S Torbenson

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