Stigmasterol Alleviates Cutaneous Allergic Responses in Rodents

BioMed Research International
Aaron Opoku AntwiClement Atobiga

Abstract

The therapeutic potential of stigmasterol, a natural steroid alcohol with established immune-modulatory properties, was assessed on allergic cutaneous responses. We examined its suppressive effect on immunoglobulin E (IgE)-mediated active cutaneous anaphylaxis (ACA), compound 48/80 (C48/80)-induced pruritus, and irritant dermatitis induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). Stigmasterol at 10-100 mg/kg significantly inhibited ACA with reduction in reaction area and concentration of the extravasated Evans blue dye. Given at 50 and 100 mg/kg, stigmasterol significantly inhibited C48/80-induced scratching behaviour when compared to saline-treated C48/80-injected control. Skin histopathology of injected sites confirmed that stigmasterol reduced mast cell trafficking and degranulation associated with C48/80-induced pruritus. Stigmasterol controlled inflammatory features such as ear skin oedema and neutrophilia and also reduced serum levels of TNFα induced by topical application of TPA. Epidermal layer thickening and inflammatory cell infiltration of ear skin tissue were significantly reduced by stigmasterol. Taken together, stigmasterol demonstrates significant potential as a molecule of interest in allergic skin disease...Continue Reading

References

Jun 1, 1992·Japanese Journal of Pharmacology·N InagakiA Koda
Jan 11, 2000·Zeitschrift Für Naturforschung. C, a Journal of Biosciences·M A GómezM A Fernández
Nov 14, 2001·Current Opinion in Clinical Nutrition and Metabolic Care·P J Bouic
Jul 30, 2002·European Journal of Pharmacology·Naoki InagakiHiroichi Nagai
Feb 20, 2003·The Journal of Allergy and Clinical Immunology·Andrew BlauveltMark C Udey
Jan 22, 2005·European Journal of Pharmacology·Michel F OtukiJoão B Calixto
May 10, 2005·Journal of Pharmacological Sciences·Yuki HashimotoShiro Nakaike
Sep 3, 2005·Nature Reviews. Immunology·Anne M Bowcock, James G Krueger
Sep 12, 2006·The Journal of Clinical Investigation·Christophe CataissonStuart H Yuspa
Jan 9, 2007·The Journal of Allergy and Clinical Immunology·Paul J DunfordRobin L Thurmond
Apr 15, 2008·Immunobiology·Martin MetzMarcus Maurer
Sep 3, 2008·Nature Clinical Practice. Rheumatology·Cindy Stahn, Frank Buttgereit
Jun 6, 2009·The Journal of Investigative Dermatology·Michael J CorkSimon J Ward
Sep 30, 2009·Osteoarthritis and Cartilage·O GabayF Berenbaum
Oct 16, 2009·Current Opinion in Immunology·Martin Metz, Marcus Maurer
Nov 26, 2009·The Journal of Allergy and Clinical Immunology·Luz S FonacierDonald Y M Leung
Jan 20, 2010·Clinics in Dermatology·Susanne BonebergerThomas Ruzicka
Feb 13, 2010·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·N B PintoF A Santos
Nov 9, 2010·Trends in Neurosciences·Steve Davidson, Glenn J Giesler
Jan 21, 2011·Clinical Reviews in Allergy & Immunology·Fu-Tong LiuHuan-Yuan Chen
Feb 9, 2011·Current Allergy and Asthma Reports·Lanny J Rosenwasser
Oct 1, 2011·Journal of Ethnopharmacology·Laryssa K RauhDaniela A Cabrini
Oct 18, 2011·European Journal of Pharmacology·Michel Fleith OtukiGennady Rosenblat
Nov 22, 2011·Facial Plastic Surgery Clinics of North America·Andrew J Heller
Oct 10, 2012·Anais Brasileiros De Dermatologia·Paulo Rowilson Cunha, Oswaldo Delfini Filho
Oct 23, 2012·Indian Journal of Pharmacology·Sang-Joon ParkEun-Joo Kim
Apr 26, 2013·The New England Journal of Medicine·Gil Yosipovitch, Jeffrey D Bernhard
Jul 17, 2013·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Thanh-Sang Vo, Se-Kwon Kim
Jun 13, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xi JinZhizhuang J Zhao
Feb 1, 2015·Naunyn-Schmiedeberg's Archives of Pharmacology·Roland Seifert
Apr 12, 2015·Handbook of Experimental Pharmacology·Robin L ThurmondAndrew J Greenspan
Mar 30, 2016·The Journal of Investigative Dermatology·Sarita SehraMark H Kaplan
Sep 20, 2016·The Journal of Clinical Investigation·Nicolas GaudenzioStephen J Galli
Dec 13, 2016·Nature Reviews. Immunology·Yvonne Bordon
May 31, 2017·Mediators of Inflammation·Aaron Opoku AntwiNewman Osafo

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Citations

Dec 13, 2019·BMC Complementary and Alternative Medicine·Nur Zahirah Abd RaniKhairana Husain
Nov 30, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Manyuan XuWeiguo Sun
Oct 13, 2020·Pharmacology & Therapeutics·Laura MasuelliRoberto Bei
May 6, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Maram B AlhawarriHabibah A Wahab
Jun 24, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Chandan SarkarAhmed Al-Rawahi

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Methods Mentioned

BETA
ELISA
enzyme-linked immunosorbent assay

Software Mentioned

GraphPad
GraphPad Prism
Image J

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