PMID: 8955286Dec 1, 1996Paper

Stigmatella aurantiaca fruiting body formation is dependent on the fbfA gene encoding a polypeptide homologous to chitin synthases

Journal of Bacteriology
B SilakowskiHans Ulrich Schairer

Abstract

Stigmatella aurantiaca is a prokaryotic organism that undergoes a multicellular cycle of development resulting in the formation of a fruiting body. For analyzing this process, mutants defective in fruiting body formation have been induced by transposon mutagenesis using a Tn5-derived transposon. About 800 bp upstream of the transposon insertion of mutant AP182 which inactivates a gene (fbfB) involved in fruiting, a further gene (fbfA) needed for fruiting body formation was detected. Inactivation of fbfA leads to mutants which form only non-structured clumps instead of the wild-type fruiting body. The mutant phenotype of fbfA mutants can be partially suppressed by mixing the mutant cells with cells of some independent mutants defective in fruiting body formation. The fbfA gene is transcribed after 8 h of development as determined by measuring the induction of beta-galactosidase activity of a fbfA-delta(trp)-lacZ fusion gene and by Northern (RNA) analysis using an insertion encoding a stable mRNA. The predicted polypeptide FbfA shows a homology of about 30% to NodC of rhizobia, an N-acetylglucosamine-transferase which is involved in the synthesis of the sugar backbone of lipo-oligosaccharides. These induce the formation of the ro...Continue Reading

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Citations

Feb 8, 2000·The Journal of Biological Chemistry·R T CarteeJ Yother
Oct 16, 1999·Glycobiology·D Kapitonov, R K Yu
Dec 23, 1999·Current Opinion in Microbiology·W Plaga, S H Ulrich
Aug 4, 2006·Archives of Biochemistry and Biophysics·Mei M Whittaker, James W Whittaker

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