Stillbirth and the small fetus: use of a sex-specific versus a non-sex-specific growth standard

Journal of Perinatology : Official Journal of the California Perinatal Association
A S TrudellAnthony O Odibo

Abstract

To determine if the use of a sex-specific standard to define small-for-gestational age (SGA) will improve prediction of stillbirth. We performed a retrospective cohort study of singleton pregnancies excluding anomalies, aneuploidy, undocumented fetal sex or birthweight. SGA was defined as birthweight <10th percentile by the non-sex-specific and sex-specific Alexander standards. The association between SGA and stillbirth using these standards was assessed using logistic regression. Among 57,170 pregnancies meeting inclusion criteria, 319 (0.6%) pregnancies were complicated by stillbirth. The area under the receiver operating characteristic curve for the prediction of stillbirth was greater for the sex-specific compared to the non-sex-specific standard (0.83 vs 0.72, P<0.001). Our findings suggest adoption of a sex-specific standard for diagnosis of SGA as it is more discriminative in identifying the SGA fetus at risk for stillbirth.

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Citations

Jul 28, 2016·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Ruofan YaoAaron B Caughey
Dec 3, 2016·International Journal of Circumpolar Health·Anna A UsyninaAlexandra Krettek
Jun 25, 2017·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Christian WidnesGanesh Acharya
Sep 11, 2018·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Ruofan YaoOzhan M Turan
May 13, 2020·Biology of Sex Differences·Zoe A Broere-BrownSarah Schalekamp-Timmermans
Dec 17, 2016·Biology of Sex Differences·Zoe A Broere-BrownEric A P Steegers
Apr 20, 2018·Biology of Sex Differences·Christian WidnesGanesh Acharya

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Methods Mentioned

BETA
SGA

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