STIM and ORAI proteins: crucial roles in hallmarks of cancer

American Journal of Physiology. Cell Physiology
A Fiorio PlaN Prevarskaya

Abstract

Intracellular Ca(2+) signals play a central role in several cellular processes; therefore it is not surprising that altered Ca(2+) homeostasis regulatory mechanisms lead to a variety of severe pathologies, including cancer. Stromal interaction molecules (STIM) and ORAI proteins have been identified as critical components of Ca(2+) entry in both store-dependent (SOCE mechanism) and independent by intracellular store depletion and have been implicated in several cellular functions. In recent years, both STIMs and ORAIs have emerged as possible molecular targets for cancer therapeutics. In this review we focus on the role of STIM and ORAI proteins in cancer progression. In particular we analyze their role in the different hallmarks of cancer, which represent the organizing principle that describes the complex multistep process of neoplastic diseases.

References

Jan 27, 2000·Cell·D Hanahan, R A Weinberg
Mar 29, 2000·The Journal of Biological Chemistry·O Mignen, T J Shuttleworth
Jun 20, 2001·Nature Reviews. Molecular Cell Biology·M J BerridgeM D Bootman
Mar 25, 2005·Physiological Reviews·Anant B Parekh, James W Putney
Dec 16, 2005·Nature·Peter Carmeliet
Jul 25, 2006·Current Biology : CB·Jonathan SoboloffDonald L Gill
Aug 22, 2006·Nature·Murali PrakriyaPatrick G Hogan
Mar 9, 2007·Biochemical and Biophysical Research Communications·Yoichiro TakahashiHiroshi Ito
Apr 25, 2007·The Journal of Biological Chemistry·Wayne I DeHavenJames W Putney
Apr 28, 2007·The Journal of Biological Chemistry·Stefan Alfred GrossVeit Flockerzi
Jun 23, 2007·Nature Reviews. Cancer·Gregory R MonteithSarah J Roberts-Thomson
Oct 2, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Suhel ParvezReinhold Penner
Nov 17, 2007·The Journal of Physiology·Olivier MignenTrevor J Shuttleworth
Feb 6, 2008·Current Biology : CB·Ilya GrigorievAnna Akhmanova
Mar 7, 2008·Nature Reviews. Molecular Cell Biology·Anna Akhmanova, Michel O Steinmetz
Apr 12, 2008·Molecular Cancer Research : MCR·Alessandra Fiorio PlaLuca Munaron
Apr 25, 2008·Nature Reviews. Cancer·H Llewelyn Roderick, Simon J Cook
May 29, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Charbel El BoustanyThierry Capiod
Jun 3, 2008·Journal of Leukocyte Biology·Michele W L TengMark J Smyth
Jul 2, 2008·Molecular and Cellular Biology·Yousang GwackAnjana Rao
Feb 3, 2009·Cancer Cell·Shengyu YangXin-Yun Huang
Mar 3, 2010·Proceedings of the National Academy of Sciences of the United States of America·Yubin ZhouPatrick G Hogan
Jul 9, 2010·Cancer Research·James E Talmadge, Isaiah J Fidler
Sep 3, 2010·Journal of Cellular and Molecular Medicine·Jeremy T SmythJames W Putney
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Jun 2, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Benedetta BussolatiGiovanni Camussi
Jun 2, 2011·Nature Reviews. Drug Discovery·Peter Carmeliet, Rakesh K Jain
Jul 23, 2011·Nature Reviews. Cancer·Natalia PrevarskayaYaroslav Shuba

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Citations

Mar 18, 2017·The Journal of Physiology·Oksana IamshanovaNatalia Prevarskaya
Feb 13, 2020·Cells·Osama M ElzamzamyLori A Hazlehurst
Jun 15, 2018·Oncotarget·Hélène CabanasNadine Déliot
Sep 13, 2020·International Journal of Molecular Sciences·Carlos Pascual-CaroFrancisco Javier Martin-Romero
Apr 18, 2018·Oncotarget·Noémie EmeriauNicolas Tajeddine
Dec 12, 2018·MAbs·Catherine J HutchingsTheodore G Clark
Apr 22, 2020·Scientific Reports·Aida M Lopez-GuerreroFrancisco Javier Martin-Romero
Aug 14, 2020·Cancers·Laura CaraviaSilviu Cristian Voinea
Nov 28, 2020·Journal of Cellular Physiology·Yi-Shyun LaiWen-Tai Chiu

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