PMID: 6104791Apr 1, 1980Paper

Stimulant and depressant effects of beta-adrenoceptor blocking agents on isolated heart muscle. A positive inotropic effect not mediated through andrenoceptors

Naunyn-Schmiedeberg's Archives of Pharmacology
A J Kaumann, J R Blinks

Abstract

The chronotropic and inotropic effects of fourteen beta-adrenoceptor blocking agents were studied in vitro on preparations of isolated heart muscle from kittens and guinea pigs. Most of the agents exert negative inotropic and chronotropic effects that increase rapidly with concentration above 10(-6) M. Exceptions are the closely related compounds practolol and atenolol, which have minimal depressant effects in concentrations as high as 2 X 10(-3) M. Dose-response relations for the depressant effects are similar for pacemaker frequency and for tension development in atrial and papillary muscle. The cardiodepressant effects of beta-blockers are non-stereospecific and are apparently unrelated to the actions of the drugs at beta-adrenoceptors. Many beta-blockers exert positive inotropic and chronotropic effects at concentrations lower than those that depress. The stimulant effects are slow in onset and do not fade. In most instances these effects are blocked by propranolol and may therefore be considered to be mediated throught beta-adrenoceptors; (-)-enantiomers are more potent than (+)-enantiomers as adrenoceptor stimulants. Adrenoceptor-mediated inotropic effects are usually more pronounced in atrial than in ventricular muscle. ...Continue Reading

References

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Apr 1, 1980·Naunyn-Schmiedeberg's Archives of Pharmacology·A J Kaumann, J R Blinks

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Citations

Aug 1, 1981·Naunyn-Schmiedeberg's Archives of Pharmacology·T H MorrisA J Kaumann
Apr 1, 1980·Naunyn-Schmiedeberg's Archives of Pharmacology·A J Kaumann, J R Blinks
Jul 5, 1994·Biochemical Pharmacology·B N WuI J Chen
Apr 25, 1989·European Journal of Pharmacology·P Y MarieR J Royer
Feb 26, 1991·European Journal of Pharmacology·S OchiS Imai
Mar 24, 1992·European Journal of Pharmacology·Y NasaY Abiko
Jul 1, 1994·General Pharmacology·B N WuI J Chen
Nov 1, 1990·Pharmacology & Toxicology·E MortensenH Refsum
Jan 1, 1984·Journal of Toxicology. Clinical Toxicology·D de WildtG de Groot
May 27, 2008·Pharmacology & Therapeutics·Alberto J Kaumann, Peter Molenaar
Jan 2, 1990·The American Journal of Cardiology·M J Antonaccio, A Gomoll
Jul 1, 1996·Journal of Cardiovascular Pharmacology·Y T LinI J Chen
May 22, 2002·Journal of Cardiovascular Pharmacology·Jwu-Lai YehIng-Jun Chen
Feb 1, 1993·Journal of Cardiovascular Electrophysiology·R Ruffy
Sep 1, 1986·British Journal of Pharmacology·A J Kaumann, B M Lobnig
Nov 1, 1993·Medicinal Research Reviews·J R Arch, A J Kaumann
Oct 29, 2000·Journal of Applied Physiology·A E Bartunek, P R Housmans
May 19, 2020·Toxicological Sciences : an Official Journal of the Society of Toxicology·Umber SaleemChris Denning

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