Stimulant 'rapid metabolizers': wrong label, real phenomena

Attention Deficit and Hyperactivity Disorders
Margaret D WeissDean Elbe

Abstract

This is a review of the empirical literature regarding what has been described anecdotally as patients who are 'rapid metabolizers' of stimulant medication. The authors propose that this is a misnomer used to describe two types of atypical pharmacokinetic patterns of response: high-dose responders, short-duration responders and two types of atypical pharmacodynamics patterns of response: patients who develop either acute or chronic tolerance. The authors propose that use of more precise terminology should facilitate both patient education and research to better understand the physiology and clinical management of atypical response patterns to stimulant treatment. Presently, the understanding of the pharmacokinetics and pharmacodynamics of psychostimulants is still quite limited. Further scientific research is needed to understand unusual patterns of pharmacological response seen in the clinic. Careful identification and precise description of these patterns would facilitate understanding the pharmacokinetics and pharmacodynamics of stimulants impacts the atypical response patterns seen in the clinic.

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Citations

Dec 1, 2018·Journal of Psychosocial Nursing and Mental Health Services·Julie A Carbray
May 29, 2019·JAMA Pediatrics·Douglas RussellMark A Stein

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