Stimulated by retinoic acid gene 8 (Stra8) plays important roles in many stages of spermatogenesis

Asian Journal of Andrology
Hai-Tao MaYing Zheng

Abstract

To clarify the functions and mechanism of stimulated by retinoic acid gene 8 (Stra8) in spermatogenesis, we analyzed the testes from Stra8 knockout and wild-type mice during the first wave of spermatogenesis. Comparisons showed no significant differences in morphology and number of germ cells at 11 days postpartum, while 21 differentially expressed genes (DEGs) associated with spermatogenesis were identified. We speculate that Stra8 performs many functions in different phases of spermatogenesis, such as establishment of spermatogonial stem cells, spermatogonial proliferation and self-renewal, spermatogonial differentiation and meiosis, through direct or indirect regulation of these DEGs. We therefore established a preliminary regulatory network of Stra8 during spermatogenesis. These results will provide a theoretical basis for further research on the mechanism underlying the role of Stra8 in spermatogenesis.

Citations

Jan 5, 2020·In Vitro Cellular & Developmental Biology. Animal·Masoumeh Majidi ZolbinJoshua Johnson
Sep 9, 2019·Cell and Tissue Research·Sakineh PanahiReza Mastery Farahani
Feb 25, 2020·Journal of Cellular and Molecular Medicine·Changmin NiuYing Zheng
Aug 15, 2018·International Journal of Molecular Medicine·Xueyi ShenYing Zheng
May 19, 2019·Andrology·J Feichtinger, R J McFarlane
Jan 5, 2021·Environmental Science and Pollution Research International·Mahammed Moniruzzaman, Nimai Chandra Saha
Jan 14, 2021·Journal of Cellular and Molecular Medicine·Xuexia LiuFujun Liu
May 5, 2021·Frontiers in Cell and Developmental Biology·Kai O SkaftnesmoAnna Wargelius
Aug 8, 2021·International Journal of Molecular Sciences·Sahar WaseemKeesook Lee

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
electrophoresis
reverse transcription-PCR
Genotyping
optical microscopy
RNA-Seq
transgenic

Software Mentioned

SPSS
SPSS18
Genecards
WEGO
NOISeq
RSEM

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.