Abstract
To evaluate plasma C-peptide levels in middle-aged and elderly patients with type II diabetes, to clarify their practical use in assessing the need for insulin therapy, and to determine their sensitivity in distinguishing insulin-requiring from non-insulin-requiring diabetes after improved baseline glycemic control. Plasma glucose and C-peptide levels were measured in a fasting state and 2 hours after an oral challenge with 100 g of glucose in groups of obese and normal-weight, glycemic-controlled, middle-aged and elderly patients with diabetes treated with insulin or an orally administered hypoglycemic agent (OHA). Basal and glucose-stimulated C-peptide levels as well as increased stimulated glucose values were contrasted in insulin- versus OHA-treated groups. In a second protocol, basal and glucose-stimulated C-peptide reactivity and stimulated glucose levels were also measured in eight patients with diabetes, before and after glycemic control. Irrespective of the age difference, stimulated C-peptide levels in the insulin-treated patients were significantly lower than those in the weight-matched OHA patients. Similarly, for both the middle-aged and elderly patients, stimulated glucose levels and degree of glucose elevation we...Continue Reading
References
Apr 1, 1991·Drugs·J E Morley, H M Perry
Dec 1, 1990·Diabetes Care·S Genuth
Nov 1, 1989·Diabetes Care·R KawamoriT Kamada
May 1, 1989·Diabetologia·H J GjessingA Frøland
Jan 1, 1988·Diabetes Research and Clinical Practice·W Berger
Jul 1, 1988·Diabetes Care·O Hother-NielsenH Beck-Nielsen
Jul 1, 1987·The Journal of Clinical Endocrinology and Metabolism·J C BeardD Porte
Sep 1, 1987·The American Journal of Medicine·J E MorleyF E Kaiser
Jan 1, 1986·Gerontology·M Kyllästinen, S Elfving
Jan 1, 1985·The Journal of Clinical Endocrinology and Metabolism·M ChenD Porte
Mar 1, 1985·Diabetes·W T GarveyO G Kolterman
May 1, 1985·Diabetologia·H L KatzeffP H Bennett
Dec 1, 1983·The Journal of Clinical Endocrinology and Metabolism·M Rendell
Jul 1, 1984·Diabetes·W J AndrewsG M Reaven
Nov 1, 1981·Diabetes Care·P G Webb, A M Bonser
Jul 1, 1982·Diabetes Care·J A ScarlettO G Kolterman
Nov 1, 1982·Diabetes Care·J B HoekstraD W Erkelens
Nov 21, 1981·British Medical Journal·H KromannE A Gale
Citations
Aug 17, 2011·Diabetic Medicine : a Journal of the British Diabetic Association·A G JonesA T Hattersley
Sep 14, 2000·Clinics in Geriatric Medicine·A Lee
Mar 5, 2002·Diabetes Care·Elias S SirajCharles Faiman
Jul 1, 1996·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·S M Genuth
Jul 15, 2004·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·A Lee, J Morley
Aug 11, 2001·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·D KumarS Madha