Stimulated human lamina propria T cells manifest enhanced Fas-mediated apoptosis

The Journal of Clinical Investigation
M BoirivantW Strober

Abstract

Lamina propria (LP) T cells respond poorly to a proliferative stimulus delivered via TCR/CD3 pathway, but retain considerable ability to respond to a stimulus delivered via CD2 costimulatory or accessory pathway. In the present study, we showed first that unstimulated LP T cells, as compared to unstimulated peripheral blood (PB) T cells, exhibit an increased level of apoptosis which is further increased following CD2 pathway stimulation, but not following via TCR/CD3 pathway stimulation. We next showed that IL-2 had a sparing effect on apoptosis of unstimulated LP T cells in that IL-2 decreased and anti-IL-2 increased apoptosis of these cells; in contrast, IL-2 had no effect on apoptosis of CD2-pathway stimulated cells. Finally, we showed that increased apoptosis of LP T cells induced by CD2-pathway stimulation is inhibited when Fas antigen is blocked by a nonstimulatory anti-Fas antibody. These studies suggest that LP T cells are characterized by increased susceptibility to Fas-mediated apoptosis most due to a downstream change in the Fas signaling pathway. Given that IFN-gamma secretion is significantly increased in LP T cells in which apoptosis is inhibited, this feature of LP T cells may represent a mechanism of regulating ...Continue Reading

References

May 1, 1977·The Journal of Clinical Investigation·D M Bull, M A Bookman
Jun 1, 1992·International Immunology·B BeverlyR H Schwartz
Jun 1, 1989·The Journal of Clinical Investigation·M G PetersR P MacDermott
Dec 1, 1993·The Journal of Experimental Medicine·M R AldersonD H Lynch
Oct 1, 1994·The Journal of Experimental Medicine·M G CifoneR Testi
Nov 1, 1994·The Journal of Experimental Medicine·V A BoussiotisL M Nadler
Jan 1, 1995·The Journal of Experimental Medicine·M R AldersonD H Lynch
Feb 2, 1995·Nature·J DheinP H Krammer
Jun 1, 1993·International Immunology·C KlasP H Krammer
Jun 1, 1995·The Journal of Experimental Medicine·T RennoH R MacDonald
Jul 1, 1993·Immunology Today·D KabelitzK Pechhold
Mar 1, 1993·Immunology Today·J SavillC Haslett
Sep 10, 1993·Cell·L A TartagliaD V Goeddel

❮ Previous
Next ❯

Citations

May 6, 1999·European Journal of Immunology·C LapentaS Fais
Feb 5, 2004·Langenbeck's Archives of Surgery·Martin H Holtmann, Peter R Galle
Apr 3, 2012·Immunologic Research·Keren Rabinowitz, Lloyd Mayer
Feb 7, 2002·Lancet·Richard J Farrell, Mark A Peppercorn
Dec 6, 2006·Immunology and Cell Biology·M L Munier, A D Kelleher
Dec 11, 2002·Journal of Internal Medicine·S Ardizzone, G Bianchi Porro
Aug 26, 1998·Scandinavian Journal of Immunology·M BaileyC Stokes
Jun 19, 2002·The Proceedings of the Nutrition Society·M BaileyC R Stokes
Oct 7, 2006·Current Opinion in Gastroenterology·J A KatzC Fiocchi
Aug 29, 2000·Inflammatory Bowel Diseases·A D Levine
Dec 18, 2002·Annals of the New York Academy of Sciences·Jan M H Van Den BrandeSander J H Van Deventer
Jul 13, 2004·Gut·M H Holtmann, M F Neurath
Oct 19, 2006·Gut·I L HuibregtseS J H van Deventer
Sep 25, 2004·Canadian Journal of Physiology and Pharmacology·S Marra, L Hoffman-Goetz
Apr 21, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Mary A ZimmermanKebin Liu
Jun 5, 2002·The Journal of Clinical Investigation·Andreas SturmClaudio Fiocchi
Nov 4, 2005·Drugs·Sandro Ardizzone, Gabriele Bianchi Porro
Nov 6, 2012·Advanced Drug Delivery Reviews·Xiaomei WangRoland W Herzog
Aug 27, 2009·Biologics : Targets & Therapy·Matteo BosaniGabriele Bianchi Porro
Jan 18, 2015·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Ulrike ErbenAnja A Kühl
Oct 8, 2011·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Giorgos BamiasSpiros D Ladas
Dec 3, 2015·Nature Reviews. Gastroenterology & Hepatology·Heitor S P de Souza, Claudio Fiocchi
Dec 3, 2004·The Surgeon : Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·P ChandranO Eremin
Apr 11, 2001·American Journal of Clinical Pathology·R CiccocioppoG R Corazza
May 14, 2011·Oral Diseases·M Boirivant, A Cossu
Aug 25, 2004·International Journal of Antimicrobial Agents·Yuji IshimatsuShigeru Kohno
Jun 16, 2009·Experimental Eye Research·Kimberly P Williams, Jena J Steinle
Jun 8, 2001·Seminars in Immunology·A D Levine, C Fiocchi
Aug 27, 2014·Archivum Immunologiae Et Therapiae Experimentalis·Stefanie SteinerBenno Weigmann

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis