Stimulated platelets release amyloid beta-protein precursor

Biochemical and Biophysical Research Communications
G ColeT Saitoh

Abstract

Human platelets can be stimulated by thrombin or ionomycin to secrete soluble truncated amyloid beta-protein precursor and particulate membrane fragments which contain C-terminal and N-terminal immunoreactive amyloid beta-protein precursor. This suggests a possible circulating source of beta-protein in serum which may play a role in the formation of amyloid deposits. The release of soluble amyloid beta-protein precursor could be involved in normal platelet physiology.

References

Mar 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·D SchubertG Cole
Jun 1, 1989·The New England Journal of Medicine·B RumbleC L Masters
Jan 1, 1989·Methods in Enzymology·J F MustardM A Packham
Nov 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·S L WagnerD D Cunningham
Oct 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·D J SelkoeT Oltersdorf
Jun 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·C L MastersK Beyreuther
Jan 1, 1986·Annals of the New York Academy of Sciences·E D Means, D K Anderson
Jul 1, 1987·Journal of Neuropathology and Experimental Neurology·G S ZubenkoB Chojnacki
May 1, 1967·British Journal of Haematology·P Wolf
Aug 16, 1984·Biochemical and Biophysical Research Communications·G G Glenner, C W Wong

❮ Previous
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Citations

Mar 1, 1994·Metabolic Brain Disease·A LeBlanc
Jan 11, 1992·Lancet·D M BowenA W Procter
Aug 22, 1992·Lancet·B Regland, C G Gottfries
Jan 1, 1992·Pharmacology & Therapeutics·A I BushC L Masters
Oct 1, 1991·Trends in Pharmacological Sciences·J Hardy, D Allsop
Oct 9, 2001·Mechanisms of Ageing and Development·A PadovaniM Di Luca
Mar 1, 1997·Neurobiology of Aging·T A DaviesE R Simons
Mar 1, 1997·Neurobiology of Aging·T A DaviesE R Simons
Nov 25, 1998·British Journal of Haematology·A HenryR Cappai
Feb 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·A TamaokaD J Selkoe
Dec 31, 1992·Annals of the New York Academy of Sciences·G M ColeT Saitoh
Mar 17, 2001·Environmental Health Perspectives·P L Whitten, H B Patisaul
Apr 20, 1994·Biochemical Pharmacology·R M Nitsch, J H Growdon
Dec 1, 1992·Journal of Neuroscience Research·L S PerlmutterH C Chui
Dec 31, 1990·Biochemical and Biophysical Research Communications·J E GardellaP D Gorevic
Dec 9, 2016·Physiology·Livius V d'UscioZvonimir S Katusic
Jul 1, 1992·Annals of Neurology·A I BushB Rumble
Nov 1, 1991·Stroke; a Journal of Cerebral Circulation·R JosephK M Welch
Sep 30, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Livius V d'UscioZvonimir S Katusic
Jun 9, 1995·The Journal of Biological Chemistry·Q X LiC L Masters
Dec 14, 2011·Journal of Neurochemistry·Stéphanie Chasseigneaux, Bernadette Allinquant
Aug 28, 1997·Biochemical and Biophysical Research Communications·M HashimotoE Masliah
May 15, 1992·Thrombosis Research·Y KomiyamaK Murata
Oct 30, 1998·The Journal of Laboratory and Clinical Medicine·T A DaviesE R Simons
Sep 15, 2004·Progress in Neuro-psychopharmacology & Biological Psychiatry·Flaminio CattabeniMonica Di Luca

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