PMID: 2115331DOI: 10.1016/0006-291x(90)91272-tJul 16, 1990Paper
Stimulated platelets release amyloid beta-protein precursor
Biochemical and Biophysical Research Communications
G ColeT Saitoh
Abstract
Human platelets can be stimulated by thrombin or ionomycin to secrete soluble truncated amyloid beta-protein precursor and particulate membrane fragments which contain C-terminal and N-terminal immunoreactive amyloid beta-protein precursor. This suggests a possible circulating source of beta-protein in serum which may play a role in the formation of amyloid deposits. The release of soluble amyloid beta-protein precursor could be involved in normal platelet physiology.
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