Stimulated-single fiber electromyography monitoring of anti-sense induced changes in experimental autoimmune myasthenia gravis

Neuroscience Research
Neli BonevaTalma Brenner

Abstract

The neuromuscular weakness associated with myasthenia gravis (MG) can be transiently relieved by pharmacological inhibitors of acetylcholinesterase (AChE). Here, we expand the anticholinesterase repertoire to include 2'-O-methyl-protected antisense oligonucleotides targeted to AChE mRNA (EN101). Using stimulated-single fiber electromyography, we show that EN101 treatment of rats with experimental autoimmune myasthenia gravis (EAMG), improved the mean consecutive difference (MCD) and blocking for 24h. This treatment was more efficient than pyridostigmine and was accompanied by marked improvement in stamina and clinical profile.

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Citations

Aug 8, 2008·Journal of Neuroimmunology·Talma BrennerItzhak Wirguin
Mar 5, 2009·Muscle & Nerve·Anna Rostedt Punga, Erik Stålberg
Jun 24, 2008·Annals of the New York Academy of Sciences·Jon D SussmanHermona Soreq
Jan 3, 2013·Annals of the New York Academy of Sciences·Jon SussmanHermona Soreq
May 31, 2015·Journal of Neuroimmunology·A I TsonisS J Tzartos
Jun 23, 2018·Expert Review of Neurotherapeutics·Shuhui WangHenry J Kaminski
Mar 20, 2010·Autoimmunity·M C SouroujonS Fuchs

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