Stimulating forebrain communications: Slow sinusoidal electric fields over frontal cortices dynamically modulate hippocampal activity and cortico-hippocampal interplay during slow-wave states

Anastasia GreenbergClayton T Dickson


Slow-wave states are characterized by the most global physiological phenomenon in the mammalian brain, the large-amplitude slow oscillation (SO; ~1Hz) composed of alternating states of activity (ON/UP states) and silence (OFF/DOWN states) at the network and single cell levels. The SO is cortically generated and appears as a traveling wave that can propagate across the cortical surface and can invade the hippocampus. This cortical rhythm is thought to be imperative for sleep-dependent memory consolidation, potentially through increased interactions with the hippocampus. The SO is correlated with learning and its presumed enhancement via slow rhythmic electrical field stimulation improves subsequent mnemonic performance. However, the mechanism by which such field stimulation influences the dynamics of ongoing cortico-hippocampal communication is unknown. Here we show - using multi-site recordings in urethane-anesthetized rats - that sinusoidal electrical field stimulation applied to the frontal region of the cerebral cortex creates a platform for improved cortico-hippocampal communication. Moderate-intensity field stimulation entrained hippocampal slow activity (likely by way of the temporoammonic pathway) and also increased shar...Continue Reading


May 15, 1992·Science·G BuzsákiK Wise
Jan 1, 1990·Cold Spring Harbor Symposia on Quantitative Biology·W SingerS Bröcher
Nov 1, 1995·Neural Computation·A J Bell, T J Sejnowski
Jan 1, 1995·Annual Review of Neuroscience·W Singer, C M Gray
Jul 29, 1994·Science·M A Wilson, B L McNaughton
Jul 31, 1998·Journal of Sleep Research·G Buzsáki
Dec 24, 2002·Neuron·Albert K Lee, Matthew A Wilson
Feb 11, 2003·Proceedings of the National Academy of Sciences of the United States of America·Anton SirotaGyörgy Buzsáki
Aug 2, 2003·Nature·Kenneth D HarrisGyörgy Buzsáki
Mar 30, 2004·Trends in Neurosciences·György BuzsákiXiao-Jing Wang
Jun 9, 2004·Nature·Reto HuberGiulio Tononi
Jun 26, 2004·Science·György Buzsáki, Andreas Draguhn
Aug 6, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Marcello MassiminiGiulio Tononi
Sep 10, 2004·Proceedings of the National Academy of Sciences of the United States of America·Matthias MölleJan Born
Sep 29, 2004·Neuron·Yang Dan, Mu-Ming Poo
Sep 29, 2004·Neuron·Matthew P Walker, Robert Stickgold
Dec 4, 2004·Learning & Memory·Francesco P BattagliaBruce L McNaughton
May 25, 2005·Journal of Sleep Research·Géraldine RauchsFrancis Eustache
Dec 14, 2005·Neuroscience·M Steriade
Jun 10, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Trish WolanskyClayton T Dickson
Jul 11, 2006·Journal of Neuroscience Methods·Nazareth P Castellanos, Valeri A Makarov
Sep 8, 2006·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Jan BornSteffen Gais
Dec 19, 2006·Nature Neuroscience·Daoyun Ji, Matthew A Wilson
Aug 30, 2007·Proceedings of the National Academy of Sciences of the United States of America·Sean M Montgomery, György Buzsáki
Jan 15, 2008·Nature Neuroscience·Joseph O'NeillJozsef Csicsvari
Apr 17, 2008·PloS One·Elizabeth A ClementClayton T Dickson
May 27, 2008·Brain : a Journal of Neurology·Nikolai AxmacherJuergen Fell
Feb 28, 2009·The European Journal of Neuroscience·Matthias MölleJan Born
Sep 15, 2009·Nature Neuroscience·Gabrielle GirardeauMichaël B Zugaro
Dec 8, 2009·Journal of Neuroscience Methods·Anil K Seth
Jan 5, 2010·Nature Reviews. Neuroscience·Susanne Diekelmann, Jan Born
Mar 5, 2010·Cerebral Cortex·Sylvain ChauvetteIgor Timofeev
Aug 27, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Simal OzenGyörgy Buzsáki
Oct 14, 2010·Physiology·Laura Lee Colgin, Edvard I Moser

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Conduction System

The cardiac conduction system is a specialized tract of myocardial cells responsible for maintaining normal cardiac rhythm. Discover the latest research on the cardiac conduction system here.

Brain-Computer Interface

A brain-computer interface, also known as a brain-machine interface, is a bi-directional communication pathway between an external device and a wired brain. Here is the latest research on this topic.