PMID: 2824387Nov 15, 1987Paper

Stimulation by EGF of the growth of EGF receptor-hyperproducing tumor cells in athymic mice

International Journal of Cancer. Journal International Du Cancer
S OzawaN Shimizu

Abstract

EGF receptor-hyperproducing cells of squamous carcinoma origin were inoculated s.c. into the bilatero-abdominal regions of athymic mice and a mini-osmotic pump containing EGF was implanted on teh back. After 2 weeks the tumors formed from 5 different cell lines in the presence of EGF weighed 3 to 6 times more than those formed in the absence of EGF. The cells recovered from these tumors maintained their original characteristics such as the amplified EGF receptor gene, high numbers of EGF receptors and a sensitivity to EGF-mediated inhibition of growth in vitro. These results suggest that EGF plays an important role in promoting growth of squamous-cell carcinoma in vivo.

References

Jan 1, 1979·Annual Review of Biochemistry·G Carpenter, S Cohen
Jan 1, 1976·Annual Review of Biochemistry·D Gospodarowicz, J S Moran
Jan 1, 1976·Experientia·S P RoseH Herschman
Mar 15, 1987·International Journal of Cancer. Journal International Du Cancer·S OzawaN Shimizu
Sep 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·H KurachiT Oka
Sep 15, 1985·Cancer Letters·E Ginsburg, B K Vonderhaar
Aug 1, 1984·The Journal of Clinical Investigation·F J Hendler, B W Ozanne
Apr 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·J E BussG N Gill

❮ Previous
Next ❯

Citations

Sep 1, 1993·Cancer Metastasis Reviews·K KhazaieR B Lichtner
Jan 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G FontaniniG Bevilacqua
Dec 20, 1990·The Journal of Steroid Biochemistry and Molecular Biology·S P RobinsonA Casazza
Aug 9, 2002·Oral Oncology·Pornchai O-charoenratSuzanne A Eccles
Jan 1, 1991·Cancer Investigation·B W EnnisR B Dickson
Nov 11, 1991·International Journal of Cancer. Journal International Du Cancer·H MizoguchiM Kuwano
Sep 15, 2005·International Journal of Cancer. Journal International Du Cancer·Mitsuhiko HanawaAkishi Ooi
Jul 30, 2014·Scientific Reports·Esak LeeAleksander S Popel
Sep 1, 1993·Journal of Cellular Physiology·R L Konger, T C Chan
Oct 11, 1991·International Journal of Dermatology·R A YatesL E King
Apr 9, 2019·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Tatsuya OnishiYuko Kitagawa
Jan 15, 1989·International Journal of Cancer. Journal International Du Cancer·S OzawaN Shimizu
Apr 22, 1991·International Journal of Cancer. Journal International Du Cancer·R FukuyamaN Shimizu
Jan 15, 1990·International Journal of Cancer. Journal International Du Cancer·K YoshidaE Tahara

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.