Stimulation by fibronectin of macrophage-mediated phagocytosis of Pseudomonas aeruginosa.

Infection and Immunity
J L KluftingerR E Hancock

Abstract

In a previous investigation it was determined that Pseudomonas aeruginosa cells taken directly from a mouse in vivo growth system were significantly more susceptible to nonopsonic phagocytosis by macrophages than were similar cells after being washed in buffer (N. M. Kelly, J. L. Battershill, S. Kuo, J. P. Arbuthnott, and R. E. W. Hancock, Infect. Immun. 55:2841-2843, 1987). It was demonstrated that a phagocytosis-promoting factor was found in the supernatant obtained from chambers incubated in the peritoneal cavities of laboratory mice or rats. The phagocytosis-promoting factor was effective with both strains of P. aeruginosa tested, using both unelicited mouse peritoneal macrophages and the P388D1 mouse macrophage cell line as the phagocytic cells. Phagocytosis enhancement was observed with in vivo-grown bacteria and with bacteria grown in vitro on agar plates, but not with bacteria grown in vitro with rapid agitation. Supernatants from mice and rats were fractionated using a fast pressure liquid chromatography gel exclusion column. The phagocytosis-promoting factor copurified with fibronectin. Furthermore, antifibronectin sera negated the phagocytosis-promoting activities of in vivo chamber supernatant, while commercial bovi...Continue Reading

References

Dec 1, 1979·Journal of Bacteriology·R E Hancock, A M Carey
Jul 1, 1986·The Journal of Infection·P A Friend
Jul 1, 1987·Reviews of Infectious Diseases·R A Proctor
Mar 1, 1985·Infection and Immunity·R A ProctorD F Mosher
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Jun 1, 1981·The Journal of Infectious Diseases·D E WoodsJ A Bass
Jun 1, 1983·The Journal of Experimental Medicine·C G PommierE J Brown

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Citations

Oct 1, 1992·Infection and Immunity·R A GarduñoW W Kay
Aug 1, 1993·Infection and Immunity·T Mork, R E Hancock

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