PMID: 490620May 21, 1979Paper

Stimulation by HCO3- of Na+ transport in rabbit gallbladder

The Journal of Membrane Biology
D CremaschiG Meyer

Abstract

Bicarbonate presence in the bathing media doubles Na+ and fluid transepithelial transport and in parallel significantly increases Na+ and Cl- intracellular concentrations and contents, decreases K+ cell concentration without changing its amount, and causes a large cell swelling. Na+ and Cl- lumen-to-cell influxes are significantly enhanced, Na+ more so than Cl-. The stimulation does not raise any immediate change in luminal membrane potential and cannot be due to a HCO3(-)-ATPase in the brush border. The stimulation goes together with a large increase in a Na+-dependent H+ secretion into the lumen. All of these data suggests that HCO3- both activates Na+--Cl- cotransport and H+--Na+ countertransport at the luminal barrier. Thiocyanate inhibits Na+ and fluid transepithelial transport without affecting H+ secretion and HCO3(-)-dependent Na+ influx. It reduces Na+ and Cl- conentrations and contents, increases the same parameters for K+, causes a cell shrinking, and abolishes the lumen-to-cell Cl- influx. It enters the cell and is accumulated in the cytoplasm with a process which is Na+-dependent and HCO3(-)-activated. Thus SCN- is likely to compete for the Cl- site on the cotransport carrier and to be slowly transferred by the cot...Continue Reading

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Citations

Nov 1, 1991·Pflügers Archiv : European journal of physiology·D CremaschiV Aliverti
May 1, 1990·Pflügers Archiv : European journal of physiology·K U PetersenJ M Winterhager
Nov 1, 1988·Pflügers Archiv : European journal of physiology·D CremaschiC Rossetti
Jan 1, 1985·Pflügers Archiv : European journal of physiology·K U PetersenJ M Winterhager
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Jan 1, 1981·The Journal of Membrane Biology·K U PetersenK Heintze
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Jan 9, 2007·The Journal of Membrane Biology·E H Larsen, N Møbjerg
May 19, 2010·The Journal of Physiology·Ruth W Muchekehu, Paul M Quinton
Jan 1, 1985·The American Journal of Physiology·K U Petersen, L Reuss
Apr 1, 1986·The American Journal of Physiology·J M WinterhagerK U Petersen
Dec 1, 1982·Biochimica Et Biophysica Acta·A G Lowe, A Lambert

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