PMID: 1202592Dec 11, 1975Paper

Stimulation by phenylephrine of myocardial alpha-adrenoceptors in the left ventricle of the cat

Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie
E Rodrigues-Pereira, J Wagner

Abstract

In the anesthetized cat phenylephrine in doses of 10(-8), 3 x 10(-8) and 10(-7) moles/kg caused an increase of dp/dt(max.) of the left ventricle without altering the heart rate. This cardiostimulating effect was inhibited by the alpha-adrenolytic drug phentolamine (10(-6) moles/kg). The beta-adrenolytic agent prindolol (10(-7) moles/kg), which inhibited the increase of dp/dt(max) evoked by isoprenaline as well as by noradrenaline did not influence the positive inotropic effect of phenylephrine, thus favouring the view that there exist myocardial alpha-adrenoceptors in the ventricle of the cat.

References

Apr 24, 1974·Naunyn-Schmiedeberg's Archives of Pharmacology·J WagnerD Reinhardt
Jan 1, 1972·European Journal of Pharmacology·J J Parr, P R Urquilla
Jan 1, 1972·Naunyn-Schmiedeberg's Archives of Pharmacology·K Starke
Jan 24, 1973·Nature: New Biology·G KunosM Nickerson
Aug 1, 1967·British Journal of Pharmacology and Chemotherapy·B G Benfey, D R Varma

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Citations

May 5, 1978·Naunyn-Schmiedeberg's Archives of Pharmacology·J Wagner, O E Brodde
Jan 1, 1988·Progress in Biophysics and Molecular Biology·H C Hartzell
Jan 1, 1984·Acta Physiologica Scandinavica·J A Ask, G Stene-Larsen
Sep 5, 2006·American Journal of Veterinary Research·Peter J PascoeBruno H Pypendop
Jun 1, 1982·The Proceedings of the Nutrition Society·D S Miller

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