Stimulation by propylthiouracil of the hexose monophosphate shunt in human polymorphonuclear leucocytes during phagocytosis

British Journal of Haematology
M F Tsan, P A McIntyre

Abstract

The effect of propylthiouracil on glucose metabolism in human polymorphonuclear leucocytes was studied. At a therapeutically achievable concentration (0.1 mM), propylthiouracil stimulated hexose monophosphate shunt activity in normal leucocytes during phagocytosis but not in resting cells. However, in the presence of hydrogen peroxide it stimulated hexose monophosphate shunt activity in resting cells, and in the soluble fraction when reduced glutathione and reduced nictotinamide adenine dinucleotide phosphate (NADPH) were also present. Propylthiouracil had nor effect on glucose-1-C oxidation in either phagocytosing or resting leucocytes obtained from two male patients with chronic granulomatous disease. Stimulation of the hexose monophosphate shunt activity in normal leucocytes during phagocytosis also was demonstrated with methimazole, thiouracil and thiourea, but not with adenine, uracil or urea. There was an apparent minimal common structure requirement in thriourea. Propylthiouracil had no effect on phagocytosis, formate oxidation, glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase or catalase activities. Thus, the stimulation of the hexose monophosphate shunt activity by propylthiouracil is dependent on hy...Continue Reading

References

Aug 1, 1970·Life Sciences. Pt. 1: Physiology and Pharmacology·P PatriarcaF Rossi
Apr 1, 1970·The Journal of Clinical Investigation·R L BaehnerM L Karnovsky
Feb 1, 1967·Biochemistry·R A Weisman, E D Korn
Feb 27, 1969·The New England Journal of Medicine·S J Klebanoff, L R White
Apr 8, 1971·The New England Journal of Medicine·S H Pincus, S J Klebanoff
Oct 1, 1971·The Journal of Experimental Medicine·M F Tsan, R D Berlin
Mar 20, 1968·Archives of Biochemistry and Biophysics·J WestR L Stjernholm
Feb 1, 1969·The American Journal of Physiology·P W Reed, J Tepperman
Mar 1, 1967·The Journal of Cell Biology·R C GrahamM L Karnovsky
Nov 1, 1967·Archives of Internal Medicine·O J MarteloA A Yunis
Nov 28, 1967·Biochimica Et Biophysica Acta·M Zatti, F Rossi
Mar 1, 1962·Archives of Biochemistry and Biophysics·J SCHULTZ, K KAMINKER
Nov 1, 1962·The Journal of New Drugs·W R TROTTER
Oct 1, 1963·The Biochemical Journal·J ROBERTS, J H QUASTEL
Jul 1, 1948·The American Journal of Medicine·E C BARTELS
Jul 1, 1947·Archives of Internal Medicine·R H WILLIAMS, G A KAY

❮ Previous
Next ❯

Citations

Mar 1, 1978·Neurology India·K RadhakrishnanJ S Chopra
Dec 1, 1981·Annals of Surgery·J T SchoutenP P Carbone
Feb 1, 1994·Journal of Neurology, Neurosurgery, and Psychiatry·R H EntingP Portegies
Mar 1, 1979·Postgraduate Medical Journal·M H Cullen, A G Stansfeld
May 1, 1980·The Journal of Clinical Investigation·M F Tsan, J W Chen
Apr 19, 2008·Inflammatory Bowel Diseases·Farooq Z RahmanAnthony W Segal
Mar 1, 1978·Journal of the Neurological Sciences·M F TsanP A McIntyre

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.