PMID: 1197782Sep 1, 1975Paper

Stimulation by prostaglandin E2 of glucagon and insulin release from isolated rat pancreas

Prostaglandins
S PekS S Fajans

Abstract

To ascertain whether prostaglandins (PG) may play a role in the secretion of glucagon and in an attempt to elucidate the conflicting observations on the effects of PG on insulin release, the isolated intact rat pancreas was perfused with solutions containing 1.1 x 10(-9) to 1.8 x 10(-5)m PGE2. In the presence of 5.6 mM glucose significant increments in portal venous effluent levels of glucagon and insulin were observed in response to minimal concentrations of 2.8 X 10(-8) and 1.4 X 10(-7) PGE2, respectively; a dose-response relationship was evident for both hormones at higher concentrations of PGE2. When administered over 60 seconds, 1.4 X 10(-6)M PGE2 resulted in a significant increase in glucagon levels within 24 seconds and in insulin within 48 seconds. Ten-minute perfusions of 1.4 X 10(-6)M PGE2 elicited biphasic release of both islet hormones; Phase I glucagon release preceded that of insulin. Both phases of the biphasic glucagon and insulin release which occurred in response to 15-minute perfusions of 10 mM arginine were augmented by PGE2. These observations indicate that PGE2 can evoke glucagon and insulin release at concentrations close to those observed by others in the extracts of rat pancreas. We conclude that PG may...Continue Reading

References

Oct 1, 1968·The Journal of Pharmacy and Pharmacology·S M KarimJ Devlin
Jul 15, 1973·Biochemical Pharmacology·P J Lefebvre, A S Luyckx
Apr 1, 1974·General and Comparative Endocrinology·F HertelendyH V Biellier
Aug 1, 1974·The Journal of Clinical Investigation·R P RobertsonE L Bierman
May 1, 1966·Metabolism: Clinical and Experimental·K E SussmanR F Timmer
Aug 28, 1965·Lancet·E SAMOLSV MARKS

❮ Previous
Next ❯

Citations

Nov 1, 1983·Prostaglandins, Leukotrienes, and Medicine·H HorieS Tarui
Apr 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·S B Pek, M F Walsh
Jun 8, 1999·Journal of the National Cancer Institute·M E MartínezD S Alberts
Jun 1, 1986·The Journal of Surgical Research·R H BellD H Rogers
Sep 1, 1980·Prostaglandins and Medicine·P SingerV Schliack
Jan 1, 1986·Diabetes/metabolism Reviews·R P Robertson
Jun 1, 1984·Prostaglandins·K L Kelly, S G Laychock
May 1, 1986·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·R H BellD H Rogers

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.