PMID: 36315Mar 1, 1979

Stimulation effect of neurotransmitters on the aromatization of testosterone by Sertoli cell-enriched cultures

Molecular and Cellular Endocrinology
G VerhoevenP De Moor


The aromatization of testosterone has been studied in Sertoli cell-enriched cultures derived from 19-day-old rats. It was found that, besides dbcAMP and FSH, several neurotransmitters have a stimulatory effect. At a concentration of 10(-5) M, the strongest effects were noted with L-isoproterenol, L-norepinephrine, L-epinephrine and D,L-synephrine. Some stimulation was observed with dopamine, whereas histamine, melatonin and serotonin as well as acetylcholine and pilocarpine were ineffective. Experiments with alpha- and beta-adrenergic antagonists suggest that beta 2- and maybe also alpha-receptors are involved. The same maximal level of stimulation was generally observed for dbcAMP, FSH and isoproterenol. No further increase in activity was obtained with combinations of these compounds. It is concluded that adrenergic agonists may play a role in testicular development and function.


Jan 21, 1980·Brain Research·G V Callard
Nov 1, 1983·Developmental Biology·F EusebiM Stefanini
May 1, 1980·Journal of Steroid Biochemistry·G Verhoeven
Sep 1, 1982·Journal of Steroid Biochemistry·G VerhoevenP De Moor
Sep 1, 1987·Journal of Steroid Biochemistry·J P Weniger, A Zeis
Jan 1, 1994·Pharmacology, Biochemistry, and Behavior·P AbsilJ Balthazart
Nov 1, 1980·Molecular and Cellular Endocrinology·G VerhoevenP De Moor
Jan 1, 1981·Molecular and Cellular Endocrinology·F F Rommerts, A O Brinkman
Jun 1, 1981·Molecular and Cellular Endocrinology·D K Pomerantz
Jun 1, 1981·Molecular and Cellular Endocrinology·J J HeindelS J Strada
Oct 1, 1981·Molecular and Cellular Endocrinology·G VerhoevenP De Moor
Jan 1, 1983·Molecular and Cellular Endocrinology·M ContiM Stefanini
Jan 1, 1984·Molecular and Cellular Endocrinology·H AttramadalV Hansson
Jan 1, 1993·The Journal of Steroid Biochemistry and Molecular Biology·L EikvarV Hansson
Mar 1, 1993·The Journal of Steroid Biochemistry and Molecular Biology·J Balthazart, A Foidart
May 1, 1995·The Journal of Steroid Biochemistry and Molecular Biology·L EikvarV Hansson
Apr 1, 1987·Clinical Biochemistry·E EldrupP Winkel
Dec 18, 2001·Brain Research. Brain Research Reviews·P AbsilJ Balthazart
May 9, 2002·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·J BalthazartG F Ball
Apr 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·A L KierszenbaumJ P Perkins
Feb 1, 1995·British Journal of Pharmacology·T KimonenM Pasanen
Nov 1, 1993·In Vitro Cellular & Developmental Biology. Animal·T W BriersH Vanderstichele
Nov 1, 1984·The American Journal of Medicine·E L KlaiberJ E Dalen
Nov 1, 1980·British Journal of Obstetrics and Gynaecology·P R KoninckxI A Brosens
Jan 1, 1984·Annals of the New York Academy of Sciences·M BenahmedJ M Saez
Jan 14, 2000·The Journal of Clinical Endocrinology and Metabolism·G Van den BergheJ D Veldhuis
May 1, 1990·Andrologia·M B CamposR S Calandra


Mar 1, 1975·Endocrinology·M J Welsh, J P Wiebe
Jul 1, 1975·Molecular and Cellular Endocrinology·J H DorringtonI B Fritz
Feb 1, 1976·Molecular and Cellular Endocrinology·M D GriswoldI B Fritz
Aug 1, 1976·Molecular and Cellular Endocrinology·I B FritzJ H Dorrington
Dec 1, 1977·Molecular and Cellular Endocrinology·I B Fritz, J H Dorrington
Oct 28, 1977·Annals of the New York Academy of Sciences·M F DallmanM H McBride
Sep 1, 1976·Endocrinology·A Steinberger, E Steinberger
Dec 1, 1976·Molecular and Cellular Endocrinology·J H DorringtonD T Armstrong
Apr 19, 1976·Biochemical and Biophysical Research Communications·M J Welsh, J P Wiebe

Related Concepts

Histamine Measurement
Testosterone Measurement
Serotonin Measurement
Estradiol, (16 alpha,17 beta)-Isomer
Structure of Interstitial Cell of Leydig
Male Gonad Development
Adrenergic Agonists

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Synapse Loss as Therapeutic Target in MS

As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at an accelerated rate. In MS, it has been shown that there is a reduction in synaptic density, which presents a potential target for treatment. Here is the latest research on synapse loss as a therapeutic target in MS.

Artificial Intelligence in Cardiac Imaging

Artificial intelligence (ai) techniques are increasingly applied to cardiovascular (cv) medicine in cardiac imaging analysis. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Social Learning

Social learning involves learning new behaviors through observation, imitation and modeling. Follow this feed to stay up to date on the latest research.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Single Cell Chromatin Profiling

Techniques like ATAC-seq and CUT&Tag have the potential to allow single cell profiling of chromatin accessibility, histones, and TFs. This will provide novel insight into cellular heterogeneity and cell states. Discover the latest research on single cell chromatin profiling here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.