Stimulation in vitro by 1,25-dihydroxy-vitamin D3 of intestinal cell calcium uptake and calcium-binding protein

Science
T Freund, F Bronner

Abstract

Treatment of duodenal tissue from rats deficient in vitamin D with 1,25-dihydroxy-vitamin D3 [1,25-(OH)2-D3] led to more than a doubling of calcium uptake by the isolated cells and the appearacne in those cells of previously undetectable calcium-binding protein (CaBP). Treatment with the precursor, 25-hydroxy-vitamin D3, was without effect on calcium uptake or CaBP. Cells from vitamin D-replete animals took up three and a half times more calcium than cells from deficient animals. This rapid (90-minute) effect of in vitro treatment with a physiological dose (4.7 X 10(-8)M) of 1,25-(OH)2-D is the first such report and is in accord with the regulatory role of the hormone-like sterol.

References

Mar 1, 1975·The American Journal of Physiology·T Freund, F Bronner
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Citations

Feb 1, 1989·Pflügers Archiv : European journal of physiology·P A LucasT Drüeke
Jul 3, 1979·Calcified Tissue International·W A GleasonD H Alpers
Aug 1, 1976·Calcified Tissue Research·F BronnerT Freund
Mar 1, 1978·Biochimica Et Biophysica Acta·D GoodwinS Edelstein
May 1, 1977·Acta paediatrica Scandinavica·L SannM Bethenod
Nov 1, 1977·The Journal of Clinical Investigation·S J Birge, R Miller
Oct 1, 1977·FEBS Letters·S EdelsteinA Harell
Feb 1, 1977·Archives of Biochemistry and Biophysics·S J StohsS Orrenius
Jan 1, 1981·The International Journal of Biochemistry·F MalkiI F Durr

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