Stimulation latency and comparison of cycling regimens in women using sacral neuromodulation

Neurourology and Urodynamics
Lauren A CadishK Noblett

Abstract

In this two-part study, we sought to define how long sacral neuromodulation users with overactive bladder should trial a new setting before attributing symptoms to that setting. Subsequently, we evaluated patient preferences of variable stimulation regimens. In the initial phase of this prospective pilot study, participants' devices were turned off and later reactivated; time to symptom recurrence and resolution were recorded. In phase two, participants trialed four settings in a masked fashion with random order. After unmasking, participants chose their preferred setting and were followed 1 year. Twelve subjects completed phase one. With the device off, the mean time to symptom recurrence was 11.25 days. Mean time to symptom regression following reactivation was 6.42 days. Combined, the 90th percentile was 15 days for symptoms to reflect the device's new setting. Among 23 women completing part two, the most popular setting at the time of unmasking was a 1-hr on, 2-hr off cycled setting chosen by 7 (30%) participants. According to published estimates of battery longevity, 14 (61%) participants chose a more energy-conserving setting at the time of unmasking. The mean difference in estimated battery longevity between the chosen a...Continue Reading

References

Oct 26, 2010·International Urogynecology Journal·Elizabeth R Williams, Steven W Siegel
Jun 29, 2011·Current Urology Reports·Bastian AmendKarl-Dietrich Sievert
Jan 28, 2015·The Journal of Urology·E Ann GormleyUNKNOWN Society of Urodynamics, Female Pelvic Medicine

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Citations

Dec 6, 2019·Neurourology and Urodynamics·Ilse M GroenendijkBertil F M Blok
Aug 25, 2020·Neuromodulation : Journal of the International Neuromodulation Society·Roman AssmannStephanie O Breukink
Dec 15, 2020·Female Pelvic Medicine & Reconstructive Surgery·Margaret G MuellerUNKNOWN Developed by the AUGS Junior Faculty Research Network.

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