Stimulation of 5-HT(2A/2C) receptors within specific hypothalamic nuclei differentially antagonizes NPY-induced feeding

Neuroreport
P J Currie, D V Coscina

Abstract

The present study examined the impact of the 5-HT(2A/2C) agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) on the feeding-stimulant action of neuropeptide Y (NPY) injected into three hypothalamic sites, the paraventricular nucleus (PVN), the perifornical hypothalamus (PFH) and the ventromedial nucleus (VMH). Injections of NPY (100-200 pmol) into each region potentiated food intake. Pretreatment with DOI (5-20 nmol) into the PVN effectively suppressed feeding elicited by PVN NPY (100 pmol). In contrast, DOI injections into the PFH and VMH failed to modify NPY-stimulated eating. This suggests that 5-HT(2A/2C) receptor modulation of NPY feeding within the hypothalamus is localized to the PVN.

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Citations

Mar 13, 2002·Pharmacology, Biochemistry, and Behavior·Paul J CurrieFarnoosh Farahmand
Sep 16, 2000·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·X LinR E Peter
May 23, 2000·Annals of Medicine·J C Halford, J E Blundell
Jun 25, 2010·Pharmacology, Biochemistry, and Behavior·Paul J CurrieKatherine E Loera
Jun 12, 2013·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·María J ManceboManuel Aldegunde
Mar 13, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·O Della ZuanaN Levens
Jun 8, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·ChuanFeng WangCatherine M Kotz
Apr 9, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Paul J CurrieJoseph R Vasselli
Aug 10, 2021·Frontiers in Endocrinology·Ting YaoTiemin Liu

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