PMID: 6403394Feb 1, 1983Paper

Stimulation of androstenedione and progesterone release by LHRH and LHRH agonist from isolated rat preovulatory follicles

Molecular and Cellular Endocrinology
R PopkinJ Jonassen

Abstract

Incubation of preovulatory rat follicles isolated from PMSG-treated immature rats for periods of less than 24 h in the presence of LHRH or LHRH agonist resulted in stimulation of basal androstenedione and progesterone release. The stimulatory effects seen were time-dependent, occurring from 2-3 h for androstenedione and from 8-20 h incubation for progesterone. Dose-dependent stimulation occurred with both LHRH agonist (in the range 5 X 10(-10) to 10(-8) M) and native LHRH (from 10(-9) to 10(-6) M), both being in the range of the reported Ka for ovarian LHRH receptors. LHRH did not enhance the stimulatory effect of 1-100 mIU hCG on androstenedione and progesterone release. These results show for the first time that LHRH and LHRH agonist can exert a stimulatory action on androgen release from isolated preovulatory follicles. This suggests that LHRH may be acting either directly at the thecal cell level or indirectly via decreased granulosa cell aromatization.

References

May 1, 1977·Endocrinology·J E Fortune, D T Armstrong
Sep 1, 1978·Endocrinology·L HambergerK Ahrén
Jul 1, 1976·Proceedings of the Society for Experimental Biology and Medicine·R H Rippel, E S Johnson
Oct 1, 1974·The Journal of Endocrinology·D T BairdR J Scaramuzzi
Apr 1, 1982·Molecular and Cellular Endocrinology·R M Sharpe, I Cooper
Jan 1, 1980·Steroids·A Makris, K J Ryan
Jan 1, 1981·Molecular and Cellular Endocrinology·A J HsuehG F Erickson

❮ Previous
Next ❯

Citations

May 1, 1991·American Journal of Reproductive Immunology : AJRI·F E StandaertJ J Michal
Sep 15, 1983·Biochemical and Biophysical Research Communications·V S Raju, P R Reddy
Oct 1, 1994·Journal of Endocrinological Investigation·A V SirotkinJ Bulla

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.