Stimulation of arachidonic acid metabolism by human slow-reacting substances

European Journal of Pharmacology
J P Seale, P J Piper


Human slow-reacting substance of anaphylaxis (SRS-A) and calcium ionophore-induced human SRS released prostaglandin-like substances and rabbit aorta contracting substance (RCS) from guinea-pig lungs. This effect was abolished by incubation of SRS-A and SRS with arylsulphatase or pretreatment of the lungs with indomethacin. Human SRS-A and SRS therefore resembled guinea-pig SRS-A in stimulating arachidonic acid metabolism. These results provide further evidence for a similar (or identical) nature of human SRS-A and SRS and suggest a possible role for slow-reacting substances in the release of prostaglandins during anaphylaxis.


Mar 7, 1980·European Journal of Pharmacology·F Al-Ubaidi, Y S Bakhle
Mar 26, 1982·European Journal of Pharmacology·M M Goldenberg, E M Subers
Oct 1, 1981·Australian and New Zealand Journal of Medicine·J P Seale
Mar 1, 1980·British Journal of Pharmacology·F BertiT Viganò
Dec 15, 1984·Biochemical Pharmacology·J H FleischW S Marshall
Jun 16, 1981·Biochemical and Biophysical Research Communications·N FeuersteinP W Ramwell

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Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.