Stimulation of bone formation by intraosseous injection of basic fibroblast growth factor in ovariectomised rats

International Orthopaedics
K NakamuraH Kawaguchi

Abstract

The effect on intraosseous bone formation of a single local injection of recombinant human basic fibroblast growth factor into trabecular bones was examined in ovariectomised osteoporotic rats. Fibroblast growth factor (400 micrograms), or the vehicle alone, was injected into the ilium at 16 weeks after ovariectomy or a simulated operation. Bone mineral density in the ovariectomised rats increased to a level similar to the latter at 2 weeks and reached a maximum at 8 weeks. After 8 weeks, BMD decreased slowly and the value at 24 weeks was still higher than that in the ovariectomised rats. Fibroblast growth factor stimulated osteoid formation in the first 2 weeks, bone volume reaching a peak at 8 weeks. From 8 to 12 weeks, bone resorption increased, resulting in decreases in bone volume to the levels of the group with simulated operations at 24 weeks. Structural analysis at 8 and 24 weeks showed that ovariectomy decreased the continuity of trabeculae and the injection of fibroblast growth factor restored it to levels higher than, or equal to, those who had the simulated operation. The present study demonstrated that intraosseous fibroblast growth factor given to ovariectomised rats restored bone volume and quality to the levels ...Continue Reading

Citations

Sep 20, 2001·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·N N AldiniF M Veronese
Dec 4, 2003·Drug Discovery Today·Richard A D Carano, Ellen H Filvaroff
Apr 20, 2000·The Journal of Clinical Investigation·A MonteroM M Hurley
Jun 3, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·C R DunstanG R Mundy
Apr 6, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·H KawaguchiY Hakeda
Oct 9, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Patricia Collin-OsdobyPhilip Osdoby
Feb 2, 2002·Journal of Drug Targeting·S A Gittens, H Uludag
Mar 26, 2004·Revue de stomatologie et de chirurgie maxillo-faciale·P Boulétreau, M T Longaker
Jan 25, 2008·Biomaterials·Guillaume MabilleauDaniel Chappard
Mar 14, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J Ignacio AguirreThomas J Wronski
Nov 17, 2009·Biochemical and Biophysical Research Communications·Yurong FeiMarja M Hurley
Mar 26, 2015·Ageing Research Reviews·Camille TagliaferriVéronique Coxam
Sep 15, 2014·Acta Biomaterialia·Laura KyllönenDavid Eglin
Nov 22, 2005·Biochemical and Biophysical Research Communications·T NaganawaM M Hurley
May 27, 2004·Journal of Biomedical Materials Research. Part a·Christopher NiedhartChristian H Siebert
Aug 23, 2006·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Min Sun ParkByung-Soo Kim
Aug 19, 2007·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Uwe MausChristopher Niedhart
Oct 24, 2007·Journal of Cellular Biochemistry·Takahiro NaganawaMarja M Hurley

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.