Stimulation of both type I and type II corticosteroid receptors blunts counterregulatory responses to subsequent hypoglycemia in healthy man

American Journal of Physiology. Endocrinology and Metabolism
Stephanie M GustavsonStephen N Davis

Abstract

Antecedent increases of corticosteroids can blunt counterregulatory responses to subsequent stress. Our aim was to determine whether prior activation of type I corticosteroid (mineralocorticoid) or type II corticosteroid (glucocorticoid) receptors blunts counterregulatory responses to subsequent hypoglycemia. Healthy volunteers participated in five randomized 2-day protocols. Day 1 involved morning and afternoon 2-h hyperinsulinemic (9 pmol.kg(-1).min(-1)) euglycemic clamps (PE; n = 14), hypoglycemic clamps (PH; n = 14), or euglycemic clamps with oral fludrocortisone (PE + F; type I agonist, 0.2 mg, n = 14), oral dexamethasone (PE + D; type II agonist, 0.75 mg, n = 13), or both (PE + F + D; n = 14). Day 2 was identical in all protocols and consisted of a 2-h hyperinsulinemic hypoglycemic clamp. Day 2 insulin (625 +/- 40 pmol/l) and glucose (2.9 +/- 0.1 mmol/l) levels were similar among groups. Levels of epinephrine, norepinephrine, glucagon, growth hormone, and MSNA were significantly blunted by prior activation of both type I and type II corticosteroid receptors to PE. Prior activation of both corticosteroid receptors also significantly blunted NEFA during subsequent hypoglycemia. Thus, levels of a wide spectrum of key counter...Continue Reading

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Citations

Jan 5, 2014·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Tanja OosthuyseIngrid Avidon
Mar 28, 2013·The American Journal of the Medical Sciences·Soonho KwonKathie Hermayer
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May 30, 2008·Physiology & Behavior·Darleen Sandoval
Nov 3, 2010·Annals of the New York Academy of Sciences·Nolawit Tesfaye, Elizabeth R Seaquist
Aug 9, 2016·The Journal of Endocrinology·Paige V Bauer, Frank A Duca
Jan 18, 2019·Psychiatry and Clinical Neurosciences·Hiroaki Hori, Yoshiharu Kim
May 29, 2010·Medicine and Science in Sports and Exercise·Karine SchaalGretchen A Casazza
May 21, 2009·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·John N Clore, Linda Thurby-Hay
May 1, 2020·The Journal of Clinical Endocrinology and Metabolism·Janet H LeungGail K Adler
Sep 11, 2020·International Journal of Molecular Sciences·Eunsoo Won, Yong-Ku Kim

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