PMID: 6166964Jan 1, 1981Paper

Stimulation of canine pancreatic polypeptide, gastrin, and gastric acid secretion by ranatensin, litorin, bombesin nonapeptide and substance P

Regulatory Peptides
I M ModlinJ H Walsh

Abstract

Four dogs with chronic gastric fistulas were give intravenous bombesin nonapeptide (B9), ranatensin, and litorin by constant infusion for 90 min at 1.2 micrograms x kg-1 on separate days. A dose response study with substance P (1.5, 3.0, 60, 18 and 54 micrograms x kg-1 x h-1) was also carried out and all tests compared to a standard protein meal (10g x kg-1). Plasma gastrin and PP were measured by radioimmunoassay and gastric acid by autobiuret titration. Substance P failed to stimulate gastric acid secretion or release either pancreatic polypeptide (PP) or gastrin. Basal gastrin levels were 8 +/-2 fmol/ml. The peak increment of gastrin released by bombesin was 95 +/- 16, ranatensin 22 +/- 6, litorin 18 +/- 4, and meal 39 +/- 5 fmol/ml. Bombesin caused significantly greater release of gastrin than a meal, litorin or ranatensin (P less than 0.01). Basal gastric secretion was 23 +/- 4 microequiv./min. B9 produced a peak acid secretion of 356 +/- 124 muequiv./min. There was no significant difference between the bombesin-like peptides (P less than 0.01). Basal plasma PP was 38 +/- 12 fmol/ml. B9 produced a peak PP increment of 600 +/- 50, litorin 137 +/- 36, ranatensin 98 +/- 11, and a meal 305 +/- 58 fmol/ml. B9 released significa...Continue Reading

References

Jan 22, 1977·Lancet·T E AdrianR C Russell
Jun 29, 1978·Nature·J WhartonA G Pearse
Dec 1, 1978·General and Comparative Endocrinology·J LechagoJ H Walsh
Oct 1, 1974·British Journal of Pharmacology·G BertacciniN Sopranzi
Jan 1, 1971·Annual Review of Pharmacology·V Erspamer
Jun 1, 1980·The Journal of Surgical Research·I M ModlinJ H Walsh

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Citations

Jan 1, 1981·Histochemistry·C J GrimmelikhuijzenN Yanaihara
Jan 1, 1982·Regulatory Peptides·J H WalshG L Rosenquist
Dec 1, 1983·Regulatory Peptides·J PriceL H Rees
Jan 1, 1986·Comparative Biochemistry and Physiology. A, Comparative Physiology·G E DukeJ A Mosher
Jan 1, 1997·Pharmacology & Therapeutics·P Holzer, U Holzer-Petsche
Jun 18, 1999·Acta Physiologica Scandinavica·L SimonsenJ Bülow
Jan 1, 1988·Annals of the New York Academy of Sciences·S R VignaP W Mantyh
Jan 1, 1988·Annals of the New York Academy of Sciences·J H WalshF Cuttitta

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