Stimulation of different pathways of T-cell functions by syngeneic tumor cells and soluble membrane proteins

Cellular Immunology
M Bertschmann, E F Lüscher

Abstract

Cells from the draining lymph nodes of DBA/2 mice bearing syngeneic intradermal P-815 tumors represent an excellent responding cell population for secondary stimulation in vitro, despite the virtual absence of response by spleen cells of the same animals. Cytotoxicity is a result of stimulation with intact mitomycin-treated tumor cells. Isolated tumor cell membranes, in the form of small vesicles, stimulated cytotoxicity to a very limited extent and inhibited the development of cytotoxic T lymphocytes over a wide range of concentrations. Membrane proteins solubilized with deoxycholate and papain had only a suppressive effect. Soluble proteins exerted their effect during the induction of cytotoxic T lymphocytes and were ineffective when present during the effector phase of cytotoxic T lymphocytes. The suppressive capacity was shown to reside in a cell population which was sensitive to treatment with monoclonal Lyt-2.1 antibody and complement but not with Lyt-1.1 antibody. This phenotype was compatible with a specific rather than a promiscuous type of suppressor effector cell.

References

Nov 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·V H EngelhardS Burakoff
Oct 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·I HellströmI D Bernstein
Apr 1, 1976·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·K J ClemetsonE F Lüscher
Jan 1, 1975·Transplantation Reviews·R K Gershon
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Related Concepts

Metazoa
Tumor Antigens
Immunologic Tumoricidal Activities
Dose-Response Relationship, Immunologic
Natural Immunosuppression
Lymph Nodes
Lymphocyte Activation
Cell Surface Proteins
Neoplasms, Experimental
TC2 Cells

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