PMID: 11309794Apr 20, 2001Paper

Stimulation of epithelial tissue migration by certain porous topographies is independent of fluid flux

Journal of Biomedical Materials Research
B A DaltonJ G Steele

Abstract

A surface with columnar pores 0.1 or 0.4 microm in diameter is shown to have a novel effect on the migration of corneal epithelial tissue sheets; migration is stimulated in a nondirectional manner with respect to migration over a planar, nonporous surface (Dalton, Evans, McFarland, and Steele, J Biomed Mater Res 1999;45:384-394; Steele, Johnson, McLean, Beumer, and Griesser, J Biomed Mater Res 2000;50:475-482). By blind-ending the pores, we show that this increase in tissue migration is not dependent on fluid flux through the pores and so appears to occur as a result of surface topography. From transmission electron micrographs, the migrating tissue appears to form either close contacts or focal adhesions at the edge of some pore channels; we speculate that this may provide a fulcrum for the enhanced migration. Scanning electron micrographs suggest that within tissue that migrates over the surfaces that contain blind-ended pores, the cells are more extensively spread than those in tissue migrating on a planar surface. The migration of disaggregated epithelial cells is enhanced on surfaces that contain 0.1- or 0.4-microm-diameter pores (compared with a planar surface), and this is similarly independent of fluid flux.

References

Apr 17, 1990·Journal of Immunological Methods·E G FischerC J Kirkpatrick
Apr 1, 1990·The Journal of Cell Biology·C H Streuli, M J Bissell
Jul 1, 1986·The American Journal of Physiology·R E SteeleJ S Handler
Nov 1, 1986·Experimental Cell Research·D M Brunette
Jul 1, 1981·Journal of Periodontal Research·C A Squier, P Collins
Jan 1, 1995·Cell Motility and the Cytoskeleton·B Wójciak-StothardC D Wilkinson
Jun 1, 1995·Cell Biology International·B Wójciak-StothardC Wilkinson
Jan 1, 1995·Journal of Biomaterials Science. Polymer Edition·A F von Recum, T G van Kooten
Jul 1, 1997·Journal of Biomedical Materials Research·M LampinM F Sigot-Luizard
May 1, 1997·Australian and New Zealand Journal of Ophthalmology·R Z XieJ G Steele
Jun 5, 1998·Biomaterials·A Curtis, C Wilkinson
Sep 2, 1998·Journal of Biomaterials Science. Polymer Edition·B A DaltonJ G Steele
Oct 17, 1998·Journal of Biomedical Materials Research·J H FittonJ G Steele
Dec 17, 1998·Biomaterials·X F WalboomersJ A Jansen
Dec 22, 1998·Journal of Biomaterials Science. Polymer Edition·A S Curtis, C D Wilkinson
May 13, 1999·Journal of Biomedical Materials Research·B A DaltonJ G Steele
Jul 9, 1999·Journal of Biomedical Materials Research·M D EvansJ G Steele
Aug 17, 1999·Journal of Biomedical Materials Research·X F WalboomersJ A Jansen
Apr 11, 2000·Journal of Biomedical Materials Research·J G SteeleH J Griesser

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Citations

May 8, 2001·Journal of Biomedical Materials Research·B A DaltonJ G Steele
May 19, 2004·Biomaterials·Catherine C BerryAdam S G Curtis
Oct 13, 2011·Tissue Engineering. Part a·Leigh G ParkinsonMark W Fear
Apr 15, 2003·Journal of Cell Science·Ana I TeixeiraPaul F Nealey
Feb 16, 2002·Experimental Eye Research·B A Dalton, J G Steele
Dec 4, 2004·Biomaterials·M D M EvansX F Walboomers
Aug 18, 2005·Journal of Biomedical Materials Research. Part a·K A DiehlC J Murphy
Mar 16, 2005·New Zealand Veterinary Journal·S O KnowlesJ Lee

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