Stimulation of gastric acid and bicarbonate secretions by calcium in guinea pig stomach and amphibian isolated mucosa

Acta Physiologica Scandinavica
G Flemström, A Garner

Abstract

Administration of Ca++ (1.5 mg/kg i.v.) increased the output of both H+ and HCO-3 from the stomach of the anesthetized guinea pig as determined by measurement of gastric intraluminal pH and pCO2. The rise in HC-3 secretion was slightly greater than that in H+, resulting in a decrease in net acidity. Fundic mucosa isolated from frogs was used to study the mechanisms of the stimulatory actions. An increase in Ca++ concentration in the nutrient (serosal) bathing solution from 1.8 to 7.2 mM stimulated H+ transport in this preparation. The effect of raising Ca++ concentration was inhibited by the histamine H2 receptor antagonist Metiamide and by increasing nutrient Mg++. Stimulation of H+ transport, sensitive to Metiamide, was also observed with the calcium ionophore A23187 (4 micrograms/ml, nutrient side). The results indicate that at the mucosal level, Ca++ stimulates H+ transport by release of histamine from mucosal stores with properties similar to those of mast cells. Transport of HCO-3 in isolated mucosae was studied after inhibition of H+ transport my metiamide. An increase in nutrient Ca++ concentration stimulated the HCO-3 transport but the calcium ionophore had no effect. This action of Ca++ was abolished by atropine (10(-...Continue Reading

References

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Citations

Apr 13, 2000·Journal of Physiology, Paris·S M BastakiA Garner
Dec 7, 2010·Autonomic Neuroscience : Basic & Clinical·Susanne Holmgren, Catharina Olsson
Dec 31, 1998·Gastroenterology·I ChengD I Soybel
Aug 1, 1985·Acta Physiologica Scandinavica·F V VegaS Mårdh
Jan 1, 1980·Upsala Journal of Medical Sciences·G Flemström
Oct 1, 1983·Scandinavian Journal of Gastroenterology·E Aadland, A Berstad
Jan 12, 2001·Physiological Reviews·E M Brown, R J MacLeod

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