Stimulation of gastrointestinal motility by loperamide in dogs

Digestive Diseases and Sciences
J FioramontiL Bueno

Abstract

The effects of loperamide on gastrointestinal motility were investigated in conscious fasted dogs chronically fitted with strain-gauge transducers on the antrum, the jejunum, and the colon. Oral administration of loperamide (0.1 mg/kg) induced, after a delay of 20-30 min, a long-lasting (8-12 hr) stimulation of gastrointestinal motility associated with a disorganization of the cyclic activity at the three levels investigated. These effects were reproduced by a subcutaneous administration at the same dose and were antagonized by previous intravenous administration of naloxone or a quaternary opiate antagonist. Intracolonic administration (0.1 mg/kg) stimulated, after a delay of 20-30 min, colonic motility only. Intracerebroventricular loperamide (1 microgram/kg) induced a long-lasting (15-20 hr) inhibition of the gastric motility and a short (2-hr) disorganization of the jejunal motor profile. These data show that oral loperamide stimulates gastrointestinal motility in dogs and involves peripheral opiate receptors.

References

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Citations

Feb 1, 1992·Digestive Diseases and Sciences·G StacherG Stacher-Janotta
Mar 21, 2013·Naunyn-Schmiedeberg's Archives of Pharmacology·Scott R ArmstrongDavid T Beattie
Jan 1, 1988·Baillière's Clinical Gastroenterology·L Bueno, J Fioramonti
Dec 1, 1995·The Australian and New Zealand Journal of Surgery·M D LevittM J Maher
Aug 1, 1990·The Journal of Pharmacy and Pharmacology·X PascaudJ L Junien
Jun 22, 2002·Gut·J Fioramonti, L Bueno
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Related Concepts

Metazoa
Taenia Coli
Canis familiaris
Intestinal Motility
Injections, Intraventricular
Subcutaneous Injections
Jejunum
Imodium
Inotropism
Naloxone, (5 beta,9 alpha,13 alpha,14 alpha)-Isomer

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