PMID: 7017734Apr 1, 1981Paper

Stimulation of glucose incorporation and amino acid transport by insulin and an insulin-like growth factor in fibroblasts with defective insulin receptors cultured from a patient with leprechaunism

Proceedings of the National Academy of Sciences of the United States of America
A B KnightS P Nissley

Abstract

Fibroblasts cultured from an infant with leprechaunism and insulin resistance have been reported to exhibit profound, selective defect in insulin binding. We now examine the effect of this defect on two acute metabolic actions of insulin thought to be mediated by the insulin receptor, glucose incorporation and N-methyl-alpha-aminoisobutyric acid (Me-AiBu) uptake. In the patient's fibroblasts, maximal insulin-stimulated glucose incorporation was less than 25% of that in control fibroblasts, whereas stimulation by hydrogen peroxide, an insulinomimetic agent that acts distal to the insulin receptor, was normal. By contrast, insulin stimulated Me-AiBu uptake to the same extent in patient's and control fibroblasts. Impaired glucose incorporation and relatively normal Me-AiBu uptake also were observed in the patient's cells with multiplication-stimulating activity, an insulin-like growth factor, despite the fact that multiplication-stimulating activity appeared to stimulate both responses in normal fibroblasts via an insulin-like growth factor receptor. The divergent effects on two hormone-stimulated functions in the patient's cells suggests differences in the coupling of a receptor to different effectors. The same coupling mechanism...Continue Reading

References

Apr 1, 1976·Diabetes·M M Rechler, J M Podskalny
May 21, 1976·Biochimica Et Biophysica Acta·S Jacobs, P Cuatrecasas
Jul 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·J M Maturo, M D Hollenberg
Jul 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·M KobayashiA H Rubenstein
Sep 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·C R KahnJ S Flier
Oct 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·S JacobsP Cuatrecasas
Nov 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·E E SchillingA M Rosenberg
Oct 1, 1979·Journal of Cellular Physiology·B V HowardP H Bennett
Mar 1, 1979·The Journal of Clinical Endocrinology and Metabolism·A J D'ErcoleA Plet
May 25, 1978·The New England Journal of Medicine·R S BarM Muggeo
Aug 1, 1978·Diabetologia·A Le Cam, P Freychet
Feb 1, 1980·American Journal of Diseases of Children·A M RosenbergM M Rechler

❮ Previous
Next ❯

Citations

Nov 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·G R Hayes, D H Lockwood
Jan 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·N LongoL J Elsas
Mar 15, 1988·European Journal of Biochemistry·J A MaassenW Möller
Nov 1, 1981·The Journal of Clinical Investigation·E E Van Obberghen-SchillingR E Humbel
Nov 1, 1989·The Journal of Clinical Investigation·S S Reddy, C R Kahn
Sep 1, 1984·Calcified Tissue International·I K Ashton, J H Soul
Jan 1, 1982·Springer Seminars in Immunopathology·L C Harrison
May 1, 1992·European Journal of Pediatrics·T MomoiH Mikawa
Jan 1, 1985·Diabetes/metabolism Reviews·S I Taylor
Mar 1, 1983·Clinics in Endocrinology and Metabolism·G GrunbergerP Gorden
Mar 1, 1984·Clinics in Endocrinology and Metabolism·K Hall, V R Sara
Feb 17, 1992·Biochimica Et Biophysica Acta·N LongoL J Elsas
Mar 1, 1984·Clinics in Endocrinology and Metabolism
May 3, 2000·Journal of Dairy Science·H A Tucker
Mar 1, 1984·The American Journal of Physiology·R L DeHaanL J Elsas

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.