PMID: 8585937Nov 1, 1995Paper

Stimulation of goblet cell mucous secretion by activation of nerves in rat conjunctiva

Current Eye Research
T L KesslerD A Dartt

Abstract

An epithelial debridement wound, as a stimulus to the cornea, causes conjunctival goblet cell mucous secretion in that eye. To determine if this stimulation of secretion is neurally mediated, rats were anesthetized and the local anesthetic lidocaine (1%) or buffer alone was administered topically and/or subconjunctivally for 15 min. A corneal epithelial debridement wound was made in one eye. The contralateral eye served as the control. After 5-120 min, animals were sacrificed and inferior bulbar conjunctival buttons removed. Mucus in the goblet cells was stained with Alcian blue and periodic acid-Schiff's reagent to indicate mucin-containing goblet cells. The number of mucin-containing goblet cells/0.16 mm2 was determined by light microscopy; a decrease in number indicated an increase in mucous secretion. Stimulation by corneal wounding induced goblet cell mucous secretion in that eye. Secretion was observed as rapidly as 5 min after stimulus and for as long as 120 min. Topical application of lidocaine, subconjunctival injection of lidocaine, or a combination of both inhibited wound-induced stimulation of mucous secretion. We conclude that conjunctival goblet cell mucous secretion can be neurally mediated and could serve as an ...Continue Reading

References

Jan 1, 1992·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·O Oduntan, G Ruskell
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Citations

Jan 30, 1999·The British Journal of Ophthalmology·M NakamuraT Hamano
Dec 4, 2004·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Michael J Doughty, Jan P G Bergmanson
Jun 29, 2004·Progress in Retinal and Eye Research·Michael E Johnson, Paul J Murphy
Nov 30, 2000·Experimental Eye Research·D A DarttJ R Rios
Jun 27, 2006·Progress in Histochemistry and Cytochemistry·Friedrich P Paulsen, Monica S Berry
Jul 24, 2015·Cornea·Stephanie M Cox, Jason J Nichols
Aug 19, 2014·Mediators of Inflammation·Ana Guzman-AranguezJesús Pintor
Jan 19, 2016·The Ocular Surface·Youngsub EomHyo Myung Kim
Aug 18, 2016·Journal of Cataract and Refractive Surgery·Denise S RyanDarlene A Dartt
May 22, 2010·Cornea·Hong-Yuan ZhuRoger W Beuerman
Jul 26, 2014·Current Opinion in Allergy and Clinical Immunology·Darlene A Dartt, Sharmila Masli
Sep 7, 2006·Current Opinion in Allergy and Clinical Immunology·Amalia Enríquez-de-Salamanca, Margarita Calonge
Apr 30, 2017·Clinical and Experimental Otorhinolaryngology·Hwan Soo KimHyun Hee Kim
Jul 15, 1998·Current Eye Research·H B ChenS Tsukahara
Aug 1, 1997·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·N A SharifW E Howe
Jul 29, 2005·Journal of Neurophysiology·David A BereiterHarumitsu Hirata
Jan 20, 2006·Journal of Anesthesia·Kimiko TakekawaYasushi Kinoshita
Mar 7, 2003·American Journal of Physiology. Cell Physiology·Harumi KannoDarlene A Dartt
Mar 28, 2002·Cornea·Hiroshi ToshidaRoger W Beuerman
Jul 26, 2018·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Cecilia ChaoMichele C Madigan
Sep 3, 2013·Experimental Eye Research·Ian D Meng, Masayuki Kurose
Jan 20, 2004·Experimental Eye Research·Darlene A Dartt

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