Stimulation of hematopoiesis by the Fms-like tyrosine kinase 3 ligand restores bacterial induction of Th1 cytokines in thermally injured mice.

Infection and Immunity
Tracy Toliver-KinskyEdward Sherwood

Abstract

Patients with large burn injuries are susceptible to opportunistic infections due to impaired functions of multiple effector cells of innate immunity and acquired immunity, including macrophages, dendritic cells (DC), natural killer (NK) cells, and T cells. The ability of a host to produce Th1 cytokines, such as gamma interferon (IFN-gamma) and interleukin-12 (IL-12), upon infectious challenge is also impaired after burn injury. Stimulation of hematopoiesis, to regenerate new immune cells, may be an effective strategy for improving resistance to infections after severe burn trauma. Fms-like tyrosine kinase 3 ligand (Flt3L) is a hematopoietic cytokine that stimulates the expansion and differentiation of NK cells and DC. Using a mouse model, we tested the hypothesis that Flt3L treatments after burn injury stimulate the production of functional effector cells of innate immunity and restore appropriate Th1 cytokine responses to Pseudomonas aeruginosa, a common source of pneumonia and wound infections in burn victims. Flt3L increased splenic cellularity in sham (uninjured) and burned mice and increased the numbers of NK cells (DX5(+)) and DC (CD11c(+)). In response to P. aeruginosa, significant increases in the serum IFN-gamma level...Continue Reading

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Citations

Nov 16, 2013·Nature Reviews. Immunology·Richard S HotchkissDidier Payen
Sep 26, 2006·Journal of Burn Care & Research : Official Publication of the American Burn Association·Zhiyu HuangEdward R Sherwood
Sep 23, 2009·Critical Care Medicine·Gerd G GauglitzMarc G Jeschke
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Feb 6, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Brandon M L LinzRobert Maile
Dec 7, 2017·Scientific Reports·Corentin LasseauxLionel Franz Poulin
Oct 17, 2018·Infection and Immunity·Tracy Toliver-KinskyCsaba Szabo
Sep 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Manabu KinoshitaShuhji Seki
Feb 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Julia BohannonTracy Toliver-Kinsky
Aug 4, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Julia BohannonTracy Toliver-Kinsky
Dec 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tracy E Toliver-KinskyEdward R Sherwood
Feb 4, 2021·Aging and Disease·Wanxue HeLixin Xie
May 8, 2018·International Immunopharmacology·Kumar Vijay

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