Stimulation of hematopoiesis in untreated and cyclophosphamide treated mice by the inhibition of prostaglandin synthesis

Journal of Immunopharmacology
D A NikcevichH T Wepsic

Abstract

Indomethacin (IN) was administered to untreated or to cyclophosphamide (CY) treated C57B1/6 mice to study the roles of prostaglandins in regulating hematopoiesis. The following hematopoietic parameters were quantitated: peripheral blood leukocyte (PBL) count; total nucleated cells per spleen; total nucleated cells per femur; and spleen weight. Assays were performed in vitro to measure the number of colony forming units (CFU) present in the bone marrow and spleen. Untreated mice administered IN had a transient rise in their PBL count. These animals also developed splenomegaly and had an increased number of nucleated cells in their spleen. All CY treated mice had a marked decrease in PBL count, spleen cellularity, bone marrow cellularity, and spleen size during the first 5 days after CY treatment. These observations were followed by hematopoietic recovery over the next 10 days. Cyclophosphamide treated mice exhibited a more rapid hematopoietic recovery when treated with IN than without IN treatment. Analysis of the CFU capacity of bone marrow and spleen cells in soft agar showed a larger number of CFU in the bone marrow and spleen of IN treated mice or of CY/IN treated mice than in animals not receiving IN. These results indicate...Continue Reading

References

Mar 1, 1978·The Journal of Experimental Medicine·J I Kurland, R Bockman
Jan 1, 1984·Cancer Immunology, Immunotherapy : CII·E SchlickM A Chirigos
Sep 1, 1981·Cell and Tissue Kinetics·L M PelusM A Moore

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Citations

May 1, 1995·Developmental and Comparative Immunology·M R JadusH T Wepsic
Jan 1, 1989·International Journal of Immunopharmacology·S J VoreM I Luster
Apr 1, 1988·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·G B Schneider, M Relfson
May 12, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Michal HoferDenisa Komůrková

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