Stimulation of heme oxygenase in macrophages and liver by endotoxin

The Journal of Clinical Investigation
D GemsaR SCHMID

Abstract

In rat peritoneal macrophages, engaged in erythrophagocytosis in vitro, endotoxin stimulated heme oxygenase (HO) activity, which was additive to the substrate-mediated enzyme induction produced by the ingested erythrocyte hemoglobin. Endotoxin neither appeared to injure the erythrocytes, nor did it enhance the rate of erythrophagocytosis. In intact rats, HO activity in both parenchymal and sinusoidal cells of the liver was increased after treatment with endotoxin. It is likely that endotoxin directly stimulates HO activity, a process which may account for the reported rise in bilirubin formation in endotoxin-treated animals. The effect of endotoxin on HO may represent part of the general activation of phagocytic cells by endotoxin.

References

Oct 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·R TenhunenR Schmid
Jun 1, 1971·The Journal of Experimental Medicine·N R PimstoneR Schmid
Nov 1, 1968·Proceedings of the Society for Experimental Biology and Medicine·C L Eddington, R F Kampschmidt
Nov 1, 1969·Archives of Internal Medicine·S E VermillionL G Bartholomew
Jul 1, 1972·The Journal of Cell Biology·D M BissellR Schmid
Sep 1, 1971·Proceedings of the Society for Experimental Biology and Medicine·J P Filkins
Jul 21, 1971·Nature: New Biology·P Alexander, R Evans
Dec 1, 1968·British Journal of Haematology·M J ClineH E Williams
Mar 4, 1967·British Medical Journal·A B Arthur, B D Wilson
Nov 1, 1960·The Journal of Experimental Medicine·S H RUTENBURGJ FINE
Jul 10, 1965·British Medical Journal·A ELEYH P LAMBERT

❮ Previous
Next ❯

Citations

Aug 1, 1994·Molecular Neurobiology·H H Fudenberg
Feb 9, 1996·Biochimica Et Biophysica Acta·T YamaguchiH Nakajima
Aug 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·R StockerB N Ames
Sep 4, 2004·Antioxidants & Redox Signaling·Roland Stocker
Oct 29, 2003·The Tohoku Journal of Experimental Medicine·Shigeki Shibahara
Dec 9, 2008·The Tohoku Journal of Experimental Medicine·Takashi MamiyaTomonori Hosoya
Jan 6, 2015·Antioxidants & Redox Signaling·Anne D Cherry, Claude A Piantadosi
Sep 1, 1976·Archives of Biochemistry and Biophysics·D M Bissell, L E Hammaker
Sep 9, 2016·Physiological Reviews·Anita AyerRoland Stocker
Apr 8, 2006·Physiological Reviews·Stefan W RyterAugustine M K Choi
Jan 1, 1990·Free Radical Research Communications·R Stocker
Jul 19, 2003·Pharmacological Reviews·Frank A D T G WagenerCarl G Figdor
Nov 12, 2014·Postgraduate Medicine·Giulia RoveriPaolo Ventura
Aug 1, 1994·Alcoholism, Clinical and Experimental Research·E Menzano, P L Carlen
Nov 1, 1978·Scandinavian Journal of Haematology·J D TorranceT H Bothwell
Mar 7, 2021·International Journal of Molecular Sciences·Anne GrunenwaldMarie Frimat
Oct 15, 1979·Archives of Biochemistry and Biophysics·S ShibaharaG Kikuchi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Jeffrey E SchmidtRobert F Tamburro
© 2021 Meta ULC. All rights reserved