PMID: 9165311Jan 1, 1997Paper

Stimulation of hepatocyte glycerolipid synthesis by iron/ADP is due to ADP rather than oxidative stress

Free Radical Biology & Medicine
J Girón-Calle, H H Schmid

Abstract

ADP-complexed Fe3+ has been used in various in vitro systems and in intact cells to induce lipid peroxidation. During studies on the effects of oxidative stress on lipid metabolism we observed a significant increase in de novo glycerolipid synthesis in Fe3+/ADP-treated rat hepatocytes as evidenced by increased [U-14C]glycerol incorporation. Here we show that this increase, largely due to enhanced triacylglycerol synthesis, is caused by ADP rather than Fe3+/ADP-induced oxidative stress. Hence, metabolic alterations due to treatment of intact cells by Fe3+/ADP must be interpreted with caution.

References

Nov 15, 1975·European Journal of Biochemistry·J HögbergP J O'Brien
Nov 15, 1975·European Journal of Biochemistry·J HögbergS Orrenius
Jan 15, 1975·European Journal of Biochemistry·J HögbergR E Larson
Jun 1, 1975·Archives of Biochemistry and Biophysics·C T HuberM Morrison
Jan 1, 1978·Advances in Lipid Research·B J Holub, A Kuksis
Jan 1, 1978·Methods in Enzymology·P MoldéusS Orrenius
Jul 9, 1991·Biochimica Et Biophysica Acta·J I MacDonald, H Sprecher
Jan 1, 1990·Methods in Enzymology·B Halliwell, J M Gutteridge
Nov 1, 1987·Chemistry and Physics of Lipids·F R Ungemach
Jan 1, 1964·Biochemical and Biophysical Research Communications·P HochsteinL Ernster
Jan 1, 1974·Annual Review of Biochemistry·H van den Bosch
Oct 1, 1995·Archives of Biochemistry and Biophysics·P C SchmidH H Schmid
Jan 1, 1995·Annual Review of Pharmacology and Toxicology·T K HardenR A Nicholas
May 10, 1995·Archives of Biochemistry and Biophysics·P C SchmidH H Schmid

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Citations

Sep 26, 2021·Metallomics : Integrated Biometal Science·Haoxuan DingJie Feng

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