Abstract
The influence of histamine (and the related agonists and antagonists) alone or in the presence of recombinant human interleukin 1 alpha (IL-1 alpha) and gamma interferon (IFN-gamma) was studied on the production of complement components C3, C2, factor B, and C4 in vitro with human monocytoid cell line U937, hepatoma-derived cell line HepG2, and mouse hepatocytes. Both U937 and HepG2 cells responded to histamine through H1 and H2 histamine receptors. The effect of histamine on the biosynthesis and gene expression of complement proteins was predominantly enhancing via the H1 histamine receptors and inhibitory through the H2 receptors. The actual predominance of the histamine receptor involved (and the outcome of the ligand interaction) seemed to be greatly affected by the simultaneous activation of the cells by IL-1 or IFN-gamma.
References
Jun 15, 1977·Journal of Molecular Biology·P W RigbyP Berg
Jun 1, 1987·Annals of the Rheumatic Diseases·D J Taylor, D E Woolley
Jan 1, 1986·Advances in Immunology·R D CampbellR R Porter
Jan 1, 1988·The Journal of Experimental Medicine·Y KatzR C Strunk
May 1, 1988·Scandinavian Journal of Immunology·E Johnson, G Hetland
May 1, 1987·Immunology Letters·E UjhelyiG Füst
Sep 1, 1985·The Journal of Clinical Investigation·R C StrunkF S Cole
Jun 6, 1974·The New England Journal of Medicine·S Ruddy, H R Colten
Sep 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·P S Thomas
Jan 1, 1984·Advances in Immunology·D J BeerR E Rocklin
Oct 1, 1982·The Journal of Clinical Investigation·K M MorrisH R Colten
May 1, 1983·Clinical Immunology and Immunopathology·F S ColeJ E Pennington
Oct 1, 1982·Molecular Immunology·H R Colten
Jun 1, 1980·European Journal of Biochemistry·C Auffray, F Rougeon
Aug 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·A S WhiteheadG Fey
Sep 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·D E WoodsH R Colten
Citations
May 1, 1991·Agents and Actions·K MeréteyT Kishimoto
Oct 17, 2012·Journal of Clinical Immunology·Zsóka WeiszhárIldikó Horváth
Feb 1, 1990·Molecular Immunology·A FalusK Merétey
Feb 1, 1990·Molecular Immunology·A FalusK Merétey
Jan 1, 1990·Comparative Biochemistry and Physiology. A, Comparative Physiology·H RokitaJ Gauldie
Jun 1, 1992·Scandinavian Journal of Immunology·H RokitaK Stalinska
Nov 1, 1992·Cytokine·A FalusT Kishimoto
Jan 30, 2018·European Journal of Pharmacology·Michael J HaasArshag D Mooradian
Jul 18, 2018·Life Sciences·Michael J HaasArshag D Mooradian
Jan 1, 1996·Clinical and Diagnostic Laboratory Immunology·T CollinsK E Sullivan
Mar 1, 1993·Glia·S R BarnumE N Benveniste