PMID: 9419366Feb 21, 1998Paper

Stimulation of HIV-1-neutralizing antibodies in simian HIV-IIIB-infected macaques

Proceedings of the National Academy of Sciences of the United States of America
S MüllerH Kohler

Abstract

Previously we have discovered a public idiotope, designated 1F7, that is expressed on antibodies against HIV type 1 (HIV-1) in human and nonhuman primates. To test the potential of mouse monoclonal antibody (mAb) 1F7 as a therapeutic anti-clonotypic antibody in HIV-1-infected patients, we used the simian HIV-IIIB macaque infection model, which mimics several immunological and pathological characteristics of HIV-1 infection in humans. Four healthy simian HIV-infected rhesus monkeys (Macaca mulatta) expressing the 1F7 marker on anti-gp120 antibodies were selected for this study. Three monkeys of this group were immunized several times with the murine mAb 1F7 i.v., and one monkey received as control an isotype-matched antibody, TEPC183. No serious side effect or allergic reaction was encountered. Blood collected before and during the immunization and over several months afterward were analyzed for neutralizing antibodies. Significant increases in breadth and potency of HIV-1-neutralizing antibody titers to one or more virus strains were detected in all three of the 1F7-immunized monkeys, but not in the control monkey immunized with TEPC183. These results show that an antibody, recognizing a public idiotope associated with anti-HIV...Continue Reading

References

Apr 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·C Y KangH Köhler
Mar 1, 1990·Mutation Research·W G AlvordJ P Creason
Jan 1, 1989·Methods in Enzymology·H KöhlerS Raychaudhuri
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Oct 1, 1993·Scandinavian Journal of Immunology·S MüllerH Köhler
Oct 1, 1994·Immunology Today·H KöhlerP L Nara

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Citations

May 4, 2001·Journal of Immunological Methods·S PichyangkulD G Heppner
Apr 13, 1999·Infectious Disease Clinics of North America·P S Hefty, R C Kennedy
Sep 14, 2001·Scandinavian Journal of Immunology·S MullerH Kohler
Mar 17, 1999·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·H KohlerP L Nara
Apr 6, 2016·Frontiers in Immunology·Heinz KohlerSrinivas V Kaveri
Apr 11, 2013·Human Vaccines & Immunotherapeutics·Matthew S ParsonsNicole F Bernard
Sep 17, 2004·International Reviews of Immunology·Sybille Muller
Aug 9, 2020·Monoclonal Antibodies in Immunodiagnosis and Immunotherapy·Heinz Kohler, Peter Nara

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