Stimulation of human granulocyte elastase by platelet factor 4 and heparin

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Stimulation of human granulocyte elastase by platelet factor 4 and heparin

Abstract

References

Platelet factor 4: an inhibitor of collagenase

Regulation of elastase-catalyzed hydrolysis of insoluble elastin by synthetic and naturally occurring hydrophobic ligands

Citations

Granule secretion markers on fluid-phase platelets in whole blood perfused through capillary tubing

Evidence for activation of platelets in the synovial fluid from patients with rheumatoid arthritis

Selective targeting of gene products with the megakaryocyte platelet factor 4 promoter

New synthesis of a platelet-specific protein: platelet factor 4 synthesis in a megakaryocyte-enriched rabbit bone marrow culture system

Human neutrophil elastase modulates platelet function by limited proteolysis of membrane glycoproteins

The susceptibility of elastin-fatty acid complexes to elastolytic enzymes

A method for the non-covalent immobilization of heparin to surfaces

Influence of granulocyte elastase-like proteinase (ELP) on platelet functions.

Mast cells: accessory cells which potentiate fibrosis

The human skin mast cell

Correlation between increased granulocyte elastase release and activation of blood coagulation in patients with lung cancer

Structure of the rat platelet factor 4 gene: a marker for megakaryocyte differentiation.

Heparin-induced structural and functional alterations of bovine trypsin

Transcriptional regulation of the rat platelet factor 4 gene: interaction between an enhancer/silencer domain and the GATA site.

Human platelet factor 4 is a direct inhibitor of human osteoblast-like osteosarcoma cell growth

Platelet-specific alpha-granule proteins and thrombospondin in bronchoalveolar lavage in the adult respiratory distress syndrome

Are platelet factor 4 and beta-thromboglobulin markers of cardiovascular disorders?

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