PMID: 2699257Nov 1, 1989

Stimulation of immunogenesis by neurotensin, pentagastrin and thymopentin and ways of its realization

Biulleten' eksperimental'noĭ biologii i meditsiny
G A BelokrylovO Ia Popova


In experiments on mice and in vitro the influence of neurotensin pentagastrin and thymopentin on the immune response, the phagocytosis of staphylococcus aureus by polymorphoneutrophil leucocytes and enzymatic activity of these cells by NBT-test were investigated. It was shown that neurotensin and thymopentin increase enzymatic and phagocytic function of polymorphoneutrophil leucocytes. Pentagastrin, as well as thymopentin stimulates the immune response, enzymatic but not phagocytic function of polymorphoneutrophil leucocytes. Immunostimulating effect of the studied peptides was realized by facility differentiation of mouse bone marrow cells into T-lymphocytes and by the interaction of the peptides with T-cells.


May 1, 1994·Biulleten' eksperimental'noĭ biologii i meditsiny·G A BelokrylovI V Molchanova


Apr 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·R S Basch, G Goldstein
Apr 26, 1963·Science·N K Jerne, A A Nordin

Related Concepts

Mice, Inbred CBA
Immune Response
Neutrophil Band Cells
Immunologic Adjuvants
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