PMID: 6977694Jan 1, 1981Paper

Stimulation of Immunoglobulin production from human B lymphocytes by Staphylococcus aureus: effects of monocytes and con A-induced suppressor cells

Microbiology and Immunology
T KasaharaK Shioiri-Nakano

Abstract

Significant immunoglobulin (Ig) production by human peripheral blood lymphocytes was induced in vitro by stimulating the cells with pokeweed mitogen (PWM) and Staphylococcus aureus Cowan I (SpA CoI). IgG, IgM, and IgA were determined by a combination of the latex fixation test and radioimmunoassay. High levels (1,000 to 5,000 microgram/ml of IgG and IgM and a lesser amount of IgA were constantly produced during 7 to 8 days of incubation with both stimulants. Ig production induced by SpA CoI stimulation was independent of the presence of T cells, while Ig production induced by PWM required T cells exclusively. Depletion of monocytes in the culture caused but a slight decrease in Ig production (particularly in the case of IgG). While the addition of a small number of monocytes enhanced IgG induction by both stimulants, coculture with an excess number of monocytes inhibited Ig induction (particularly IgG) by PWM stimulation but not by SpA CoI stimulation. Marked suppression of Ig production (IgG, IgM, and IgA) was observed in cocultures with Con A-activated T cells. The phenomena of suppression were observed in both the SpA CoI-stimulated and PWM-stimulated lymphocytes. These data indicated that Ig production from B cells and rela...Continue Reading

References

May 1, 1976·The Journal of Experimental Medicine·L ShouR A Good
Mar 1, 1978·The Journal of Clinical Investigation·N I AbdouN L Abdou
Feb 1, 1978·European Journal of Immunology· LêthibichthuyJ Brochier
May 10, 1979·Journal of Immunological Methods·M Madsen, H E Johnsen
Nov 3, 1977·The New England Journal of Medicine·J S GoodwinR C Williams
Jan 1, 1981·Journal of Immunological Methods·T KasaharaK Shioiri-Nakano

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