Stimulation of in vivo dopamine transmission and intravenous self-administration in rats and mice by JWH-018, a Spice cannabinoid

Neuropharmacology
Maria Antonietta De LucaG Di Chiara

Abstract

The synthetic cannabinoid 1-pentyl-3-(1-naphthoyl)-indole (JWH-018) has been detected in about 140 samples of a smokable herbal mixture termed "Spice". JWH-018 is a CB1 and CB2 agonist with a higher affinity than Δ(9)-THC. In order to investigate the neurobiological substrates of JWH-018 actions, we studied by microdialysis in freely moving rats the effect of JWH-018 on extracellular dopamine (DA) levels in the nucleus accumbens (NAc) shell and core and in the medial prefrontal cortex (mPFC). JWH-018, at the dose of 0.25 mg/kg i.p., increased DA release in the NAc shell but not in the NAc core and mPFC. Lower (0.125 mg/kg) and higher doses (0.50 mg/kg) were ineffective. These effects were blocked by CB1 receptor antagonists (SR-141716A and AM 251) and were absent in mice lacking the CB1 receptor. Ex vivo whole cell patch clamp recordings from rat ventral tegmental area (VTA) DA neurons showed that JWH-018 decreases GABAA-mediated post-synaptic currents in a dose-dependent fashion suggesting that the stimulation of DA release observed in vivo might result from disinhibition of DA neurons. In addition, on the "tetrad" paradigm for screening cannabinoid-like effects (i.e., hypothermia, analgesia, catalepsy, hypomotility), JWH-018,...Continue Reading

References

Sep 1, 1990·Journal of Neuroscience Methods·G Di Chiara
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·G Di Chiara, A Imperato
Nov 4, 1988·Science·G F Koob, F E Bloom
Mar 7, 1998·European Journal of Pharmacology·G L GessaM Diana
Jun 15, 1999·Progress in Neurobiology·A Ameri
Aug 25, 2000·Psychopharmacology·J F CheerC A Marsden
Oct 18, 2002·Neuron·Wolfram Schultz
Mar 5, 2003·The International Journal of Eating Disorders·Nora D VolkowNaomi Pappas
Oct 7, 2004·Neuropharmacology·Gaetano Di ChiaraDaniele Lecca
Nov 27, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Miriam MelisMarco Pistis
Jun 21, 2005·Neuroscience and Biobehavioral Reviews·Marianne Fillenz
Oct 20, 2007·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Gianluigi Tanda
Aug 30, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Matthijs G BossongRené S Kahn
Oct 30, 2008·Frontiers in Integrative Neuroscience·Monica R F HilárioRui M Costa
Dec 17, 2008·Neurotoxicity Research·Roy A Wise
May 1, 2010·Forensic Science International : Synergy·Tim SobolevskyGrigory Rodchenkov
Sep 15, 2010·Analytical and Bioanalytical Chemistry·Annette WintermeyerKatja Bender
Feb 15, 2011·Drug and Alcohol Dependence·Susanna Every-Palmer
Oct 4, 2011·Annual Review of Pharmacology and Toxicology·Nora D VolkowDardo Tomasi
Nov 9, 2011·Neuropharmacology·M A De LucaG Di Chiara
Dec 1, 2011·Drug and Alcohol Dependence·Jenny L WileyJohn W Huffman
Dec 2, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Aya Matsui, John T Williams
Dec 16, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Salvatore LeccaMarco Pistis
Mar 13, 2012·Chemical Research in Toxicology·Kathryn A SeelyPaul L Prather
Apr 7, 2012·Nature Medicine·Marisela Morales, Antonello Bonci
May 9, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Kathryn A SeelyLiana Fattore
Jul 11, 2012·Drug and Alcohol Dependence·Jason M WiebelhausLaura E Wise
Jul 25, 2013·Human Psychopharmacology·Duccio PapantiTommaso Bonavigo
Jun 3, 2014·Pharmacology, Biochemistry, and Behavior·Jenny L WileyJulie A Marusich
Sep 19, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Miriam MelisMarco Pistis
Nov 14, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michael H BaumannJenny L Wiley
Jun 21, 2015·Neurobiology of Learning and Memory·Jarid Goodman, Mark G Packard

❮ Previous
Next ❯

Citations

Jan 19, 2016·Progress in Neuro-psychopharmacology & Biological Psychiatry·Andrea OssatoMatteo Marti
Apr 21, 2016·Neuroscience and Biobehavioral Reviews·Liana Fattore, Marco Diana
Nov 29, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Dicky StruikLiana Fattore
Jun 28, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·J M Wenzel, J F Cheer
Aug 29, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Leigh V Panlilio, Zuzana Justinova
Jun 28, 2018·Addiction Biology·Maria A De LucaGaetano Di Chiara
Jul 12, 2017·Behavioural Pharmacology·Nicholas PintoriMaddalena Mereu
Nov 19, 2019·Frontiers in Neuroscience·Sabrine BilelMatteo Marti
Sep 8, 2017·Frontiers in Psychiatry·Aviv M WeinsteinEdythe D London
Oct 28, 2019·Drug and Chemical Toxicology·Duygu MutluayCennet Sinem Çoban
Jan 10, 2020·Frontiers in Pharmacology·Cristina MilianoMaria Antonietta De Luca
Feb 14, 2020·International Journal of Molecular Sciences·Monia LenziMatteo Marti
Jan 30, 2018·Drug Metabolism Reviews·Mary Tresa Zanda, Liana Fattore
Sep 10, 2020·Brain Sciences·Liana FattoreMaria Paola Castelli
Sep 26, 2020·The European Journal of Neuroscience·Tibor M Brunt, Matthijs G Bossong
Dec 30, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wonyoung LeeHyun-Ju Park
Nov 4, 2017·Pharmacology & Therapeutics·Laura HondebrinkRemco H S Westerink

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here