Stimulation of insulin and somatostatin release by two meglitinide analogs

Endocrine
V Leclercq-MeyerW J Malaisse

Abstract

Several meglitinide analogs are currently under investigation as potential insulinotropic tools for the treatment of noninsulin-dependent diabetes. The present study aimed to further insight into the effect of these agents on the secretion of insulin, glucagon, and somatostatin by the isolated perfused pancreas. Both repaglinide (0.01 microM) and A-4166 (1.0 microM) stimulated insulin and somatostatin release, but failed to affect glucagon output, from pancreases exposed to 5.6 mM D-glucose. The secretory response of the B- and D-cells to the hypoglycemic agents was much less marked than that caused by a rise in hexose concentration from 5.6-16.7 mM. Although repaglinide was tested at a concentration a hundred times lower than that of A-4166, the drug-induced increase in both insulin and somatostatin secretion persisted for a longer time after exposure to repaglinide, than to A-4166. The relevance of these findings to the use of meglitinide analogs as antidiabetic agents is double. First, they document that these drugs, although enhancing both insulin and somatostatin release, do not provoke an undesirable stimulation of glucagon secretion. Second, they indicate that even at a very low concentration, repaglinide provokes a prot...Continue Reading

References

Oct 1, 1976·Diabetologia·V Leclercq-MeyerW J Malaisse
Feb 1, 1967·Proceedings of the Society for Experimental Biology and Medicine·W J MalaisseP H Wright
Oct 1, 1967·The American Journal of Physiology·W J MalaisseP H Wright
Jul 1, 1984·Acta Physiologica Scandinavica·P G BurholR Jorde
Jun 1, 1995·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·W J Malaisse
Sep 1, 1996·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·H JijakliW J Malaisse
Jan 1, 1997·Fundamental & Clinical Pharmacology·H JijakliW J Malaisse

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Citations

Nov 27, 2002·European Journal of Pharmacology·Franco GregorioPaolo Filipponi
Jun 26, 1999·European Journal of Clinical Investigation·W J Malaisse
Jan 29, 2005·British Journal of Pharmacology·Ann Maria K HansenPhilip Wahl
Sep 18, 2004·Metabolism: Clinical and Experimental·V A FonsecaJ E Gerich
Dec 25, 2013·International Journal of Molecular Medicine·Willy J Malaisse
Apr 13, 1999·The American Journal of Physiology·V Leclercq-MeyerW J Malaisse
Oct 1, 1998·The American Journal of Physiology·V Leclercq-Meyer, W J Malaisse

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