PMID: 9545083Apr 17, 1998Paper

Stimulation of L-type Ca2+ channel in growth cones activates two independent signaling pathways

Journal of Neuroscience Research
K OhbayashiM Igarashi

Abstract

Although growth cones respond to various modulators of neurite outgrowth, such as neurotrophins, neurotransmitters, and cell adhesion molecules, the signal-transducing mechanisms for these modulators in growth cones are unclear. Since recent studies have suggested that the signals of these modulators are mediated by Ca2+ influx through L-type voltage-sensitive Ca2+ channels (VSCCs) in the growth cone, we examined L-type VSCC-dependent signaling pathways, using isolated growth cones (IGCs) from developing rat forebrains. Binding assays revealed that L-type VSCC is enriched in growth cone membrane and gradually decreased in amount developmentally, while N-type VSCC has the opposite tendency. In intact IGCs, Bay K 8644 (BK, an L-type agonist) induced much more rapid elevation of [Ca2+]i than that in adult synaptosomes. Ca2+-dependent phosphorylation of GAP-43 and MARCKS protein by protein kinase C (PKC) was enhanced in the IGC by BK, resulting in the release of these proteins from the membrane, which is consistent with our recent report. In addition, the Ca2+-dependent degradation of brain spectrin (fodrin) by calpain was also enhanced by BK or GABA, consequently inducing the release of alpha-actinin from the membrane skeleton of ...Continue Reading

Citations

Sep 15, 2007·The Journal of Clinical Investigation·Jason S GroshongChristopher M Gomez
Dec 18, 2013·Cell Communication and Signaling : CCS·Lifu ShengVladimir Sytnyk
Sep 24, 2008·The Journal of Cell Biology·Vsevolod BodrikovMelitta Schachner
Apr 9, 2010·The European Journal of Neuroscience·Chessa S ScullinL Donald Partridge
Oct 24, 2002·Neurological Research·Agahan UnluBermans J Iskandar
Feb 13, 2001·Experimental Neurology·M FountoulakisG Lubec
Nov 22, 2000·Molecular and Cellular Neurosciences·P DohertyE J Williams
Jun 22, 2000·Journal of Neuroscience Research·M IgarashiY Komiya
Aug 24, 2007·The European Journal of Neuroscience·Kristy Welshhans, Vincent Rehder
Dec 17, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Makoto HiguchiTakaomi C Saido
Dec 4, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Vitaliy StarostaAlexander Kurosky
Oct 25, 2001·Brain Research. Developmental Brain Research·F R Zolessi, C Arruti
Dec 28, 2000·Progress in Neuro-psychopharmacology & Biological Psychiatry·H FukuraM Igarashi
Apr 7, 2000·Brain Research. Brain Research Reviews·M F Mehler

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.