PMID: 9657283Jul 10, 1998Paper

Stimulation of liver heme oxygenase in hexachlorobenzene-induced hepatic porphyria

Archives of Toxicology
M D StonardF De Matteis

Abstract

We have measured liver heme oxygenase, a heat shock protein known to be increased under conditions of oxidative stress, to obtain additional evidence for an oxidative stress mechanism in hepatic uroporphyria induced by hexachlorobenzene (HCB). We have studied heme oxygenase at different times during HCB treatment and in two strains of rats (Agus and Wistar strains), which are known to differ in their sensitivity to the porphyria-inducing properties of HCB, in order to ascertain whether the same time course and genetic differences known to exist for the induction of porphyria also apply to hepatic oxidative stress. HCB induced heme oxygenase and accumulation of porphyrins in the liver of rats of both strains; no significant difference was found between the two strains in the HCB-induced heme oxygenase activity. The increased activity of the enzyme was first detected during the early phases of treatment, when a modest increase in liver porphyrins was observed; heme oxygenase remained at induced levels for several weeks during HCB treatment, and was still raised when an increase in total liver iron content and the onset of marked porphyria were also found. In contrast to the effects of HCB, phenobarbitone sodium (given in the drin...Continue Reading

Citations

May 29, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M Fernandez, H L Bonkovsky
Nov 18, 2000·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP· De Catabbi SCBL C de Viale
May 26, 2004·Environmental Health Perspectives·Janine EzendamJoseph G Vos
Feb 13, 2003·The Journal of Pathology·Chang-Li WeiWei-Min Hon

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