Stimulation of lymphocyte migration by endotoxin, tumor necrosis factor, and interferon

Cellular Immunology
T B Issekutz, J M Stoltz

Abstract

Since several studies have demonstrated that lipopolysaccharide (LPS), tumor necrosis factor (TNF), and interleukin-1 (IL-1) enhanced lymphocyte binding to endothelial cells in vitro, we examined the effects of these agents on lymphocyte migration in vivo. Small peritoneal exudate lymphocytes (sPEL), which perferentially migrate into inflammatory sites, were radiolabeled with 111In and injected iv into rats. The id injection of LPS was a strong stimulus for the migration of these cells into the skin. TNF alpha was also a good stimulator of lymphocyte migration, while TNF beta and IL-1 alpha were weak or nearly inactive. Kinetic analysis demonstrated that migration to TNF was rapid, with a peak at 6 hr, followed by a steady decline, while migration to LPS was sustained for 24 hr. TNF alpha, TNF beta, and IL-1 alpha, when combined with interferon-gamma (IFN-gamma) or IFN-alpha/beta produced striking synergistic increases in lymphocyte migration. Combinations of the TNFs and IL-1 had less than additive effects, as did combinations of the IFNs. Qualitatively similar migration responses were found when spleen T cells instead of sPEL were studied.

References

Nov 8, 1985·Science·L J Old
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·M P BevilacquaM A Gimbrone
Oct 24, 1986·Science·K J TraceyJ D Albert
Dec 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·J R GambleM A Vadas
Sep 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·D PennicaD V Goeddel

❮ Previous
Next ❯

Citations

Jun 25, 1991·European Journal of Pharmacology·E J LiP V Halushka
Dec 1, 1990·Journal of the Neurological Sciences·R D Simmons, D O Willenborg
Aug 31, 1991·Lancet·S R BakerP C Beverley
Jan 1, 1993·The Journal of Experimental Medicine·J L BaronC A Janeway
Aug 2, 2006·The Journal of Experimental Medicine·Ronjon ChakravertyMegan Sykes
Jan 15, 1998·Plastic and Reconstructive Surgery·J L SempleJ P Szalai
Jul 28, 1990·BMJ : British Medical Journal·M Jahangiri, J H Wyllie
Feb 2, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andrew C Issekutz, Thomas B Issekutz
Apr 13, 1999·The American Journal of Physiology·J B DicksteinJ B Hay
Jun 1, 1991·European Journal of Immunology·B ClinchyG Möller
Feb 6, 2010·The American Journal of Pathology·Jiqiu ChenSima T Tarzami

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.