PMID: 8582790Sep 1, 1995Paper

Stimulation of macrophages with IFN gamma or TNF alpha shuts off the suppressive effect played by PGE2

International Journal of Immunopharmacology
A ZicariG M Pontieri

Abstract

PGE2 has been shown to be able to interfere with various lymphocyte and macrophage functions, but its effects on macrophage activation are still unclear. In this study, carried out on peritoneal macrophages obtained from healthy, tumour-bearing and Corynebacterium parvum-treated mice, we demonstrated that PGE2 is involved in the down-regulation of macrophage activation, but it cannot exert its inhibiting effect when macrophages are further stimulated with activating cytokines, such as IFN gamma and TNF alpha. Our findings provide new insight into how macrophage tumoricidal activity may be induced and maintained even in presence of significant levels of PGE2.

References

Mar 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·O J PlesciaT Shimamura
Nov 1, 1973·The Journal of Cell Biology·J P Cox, M L Karnovsky
Nov 1, 1984·Prostaglandins, Leukotrienes, and Medicine·O J PlesciaM Lipari

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